Apico-basal polarity is typical of cells present in differentiated epithelium while front-rear
polarity develops in motile cells. In cancer development, the transition from epithelial to …

Convergent extension (CE) is a fundamental and conserved collective cell movement that
forms elongated tissues during embryonic development. Thus far, studies have …

How tissue shape emerges from the collective mechanical properties and behavior of
individual cells is not understood. We combine experiment and theory to study this problem …

The vertebrate neural tube forms as a result of complex morphogenetic movements, which
require the functions of several core planar cell polarity (PCP) proteins, including Vangl2 …

Motile airway cilia that propel contaminants out of the lung are oriented in a common
direction by planar cell polarity (PCP) signaling, which localizes PCP protein complexes to …

The planar cell polarity (PCP) signaling pathway is a potent developmental regulator of
directional cell behaviors such as migration, asymmetric division and morphological …

The number of patients diagnosed with chronic bile duct disease is increasing and in most
cases these diseases result in chronic ductular scarring, necessitating liver transplantation …

The establishment of polarity within tissues and dynamic cellular morphogenetic events are
features common to both developing and adult tissues, and breakdown of these programs is …

The planar cell polarity (PCP) pathway is a cell-contact mediated mechanism for transmitting
polarity information between neighboring cells. PCP “core components”(Vangl, Fz, Pk, Dsh …

Planar cell polarity (PCP) refers to the capacity of a tissue, typically, but not exclusively, an
epithelium, to transmit directional information across the tissue plane such that its cellular …