Contributing factors to poor functional recovery after delayed nerve repair: prolonged axotomy

SY Fu, T Gordon - Journal of Neuroscience, 1995 - Soc Neuroscience
The contribution of prolonged motoneuron axotomy to the poor functional recovery after
delayed nerve repair was determined by means of a nerve cross-anastomosis paradigm in …

A survey of spinal dorsal horn neurones encoding the spatial organization of withdrawal reflexes in the rat

J Schouenborg, HR Weng, J Kalliomäki… - Experimental brain …, 1995 - Springer
The withdrawal reflex pathways to hindlimb muscles have an elaborate spatial organization
in the rat. In short, the distribution of sensitivity within the cutaneous receptive field of a …

Topographical distribution of motor fascicles in the sciatic‐tibial nerve of the rat

J Badia, A Pascual‐Font, M Vivó, E Udina… - Muscle & …, 2010 - Wiley Online Library
Abstract Knowledge of the intraneural topography of peripheral nerves may help to improve
nerve repair after injuries and the selectivity of neural interfaces. We studied the fascicular …

Direct evidence for decreased presynaptic inhibition evoked by PBSt group I muscle afferents after chronic SCI and recovery with step‐training in rats

G Caron, JN Bilchak, MP Côté - The Journal of physiology, 2020 - Wiley Online Library
Key points Presynaptic inhibition is modulated by supraspinal centres and primary afferents
in order to filter sensory information, adjust spinal reflex excitability, and ensure smooth …

Effect of spinal cord injury severity on alterations of the H-reflex

JK Lee, GS Emch, CS Johnson, JR Wrathall - Experimental neurology, 2005 - Elsevier
The monosynaptic motoneuron response to stimulation of Ia afferents is known to be altered
by spinal cord injury (SCI). Although the Hoffman (H)-reflex is a tool that is often used to …

Dendritic spine dysgenesis contributes to hyperreflexia after spinal cord injury

SP Bandaru, S Liu, SG Waxman… - Journal of …, 2015 - journals.physiology.org
Hyperreflexia and spasticity are chronic complications in spinal cord injury (SCI), with limited
options for safe and effective treatment. A central mechanism in spasticity is hyperexcitability …

PAK1 inhibition with Romidepsin attenuates H‐reflex hyperexcitability after spinal cord injury

SD Kauer, CA Benson, JM Carrara… - The Journal of …, 2024 - Wiley Online Library
Hyperreflexia associated with spasticity is a prevalent neurological condition characterized
by excessive and exaggerated reflex responses to stimuli. Hyperreflexia can be caused by …

Morphological changes of the soleus motoneuron pool in chronic midthoracic contused rats

P Bose, R Parmer, PJ Reier, FJ Thompson - Experimental Neurology, 2005 - Elsevier
This study investigated the morphological features of the soleus motoneuron pool in rats
with chronic (4 months), midthoracic (T8) contusions of moderate severity. Motoneurons …

Conditional Astrocyte Rac1KO Attenuates Hyperreflexia after Spinal Cord Injury

CA Benson, KL Olson, S Patwa, SD Kauer… - Journal of …, 2024 - Soc Neuroscience
Spasticity is a hyperexcitability disorder that adversely impacts functional recovery and
rehabilitative efforts after spinal cord injury (SCI). The loss of evoked rate-dependent …

Altered patterns of reflex excitability, balance, and locomotion following spinal cord injury and locomotor training

PK Bose, J Hou, R Parmer, PJ Reier… - Frontiers in …, 2012 - frontiersin.org
Spasticity is an important problem that complicates daily living in many individuals with
spinal cord injury (SCI). While previous studies in human and animals revealed significant …