Background Familial chylomicronemia syndrome is a genetic disorder associated with
severe hypertriglyceridemia and severe acute pancreatitis. Olezarsen reduces the plasma …

BACKGROUND Reducing the levels of triglycerides and triglyceride-rich lipoproteins
remains an unmet clinical need. Olezarsen is an antisense oligonucleotide targeting …

Nucleic acid-based therapies are being rapidly developed for prevention and management
of cardiovascular diseases (CVD). Remarkable advancements have been achieved in the …

Importance Severe hypertriglyceridemia (sHTG) confers increased risk of atherosclerotic
cardiovascular disease (ASCVD), nonalcoholic steatohepatitis, and acute pancreatitis …

ABSTRACT Introduction Apolipoprotein (apo) C-III, a key regulator of plasma triglyceride
(TG) levels, is a prime candidate for the treatment of hypertriglyceridemia (HTG), prevention …

Rationale Lipoprotein lipase (LPL) deficiency, a rare inherited metabolic disorder, is
characterized by high triglyceride (TG) levels and life-threatening acute pancreatitis. Current …

Abstract Background and Aim Acute pancreatitis (AP) is a complex disease most commonly
caused by gallstones, alcohol intake, or hypertriglyceridemia. Even in subjects with …

Abstract Purpose of Review Multiple agents are being developed that inhibit apolipoprotein
(apo) C-III. This state-of-the-art review examines their potential for atherosclerotic …

Triglycerides play a crucial role in the efficient storage of energy in the body. Mild and
moderate hypertriglyceridemia (HTG) is a heterogeneous disorder with significant …

Hyperlipidemia is a common cause of acute pancreatitis (AP), often leading to more severe
clinical symptoms. The mortality factor 4-like protein 1 (MORF4L1, also called MRG15) plays …