Mechanical properties of extracellular matrices (ECMs) regulate essential cell behaviours,
including differentiation, migration and proliferation, through mechanotransduction. Studies …

In recent decades, collagen is one of the most versatile biomaterials used in biomedical
applications, mostly due to its biomimetic and structural composition in the extracellular …

The physical and architectural cues of the extracellular matrix (ECM) play a critical role in
regulating important cellular functions such as spreading, migration, proliferation, and …

Collagen is the most frequently used protein in the fields of biomaterials and regenerative
medicine. Within the skin, collagen type I and III are the most abundant, while collagen type …

The tumor microenvironment (TME) is comprised of many different cell populations, such as
cancer-associated fibroblasts and various infiltrating immune cells, and non-cell …

Mechanical loading is an important factor in musculoskeletal health and disease. Tendons
and ligaments require physiological levels of mechanical loading to develop and maintain …

ABSTRACT The α1β1, α2β1, α10β1 and α11β1 integrins constitute a subset of the integrin
family with affinity for GFOGER-like sequences in collagens. Integrins α1β1 and α2β1 were …

Pulmonary fibrosis is a chronic lung disease characterized by excessive accumulation of
extracellular matrix (ECM) and remodeling of the lung architecture. Idiopathic pulmonary …

Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, fibrosing interstitial lung
disease (ILD) of unknown aetiology, with a median survival of 2–4 years from the time of …

Wound dressing biomaterials are increasingly being designed to incorporate bioactive
molecules to promote healing, but the impact of matrix mechanical properties on the biology …