Abstract Calcium (Ca2+) signalling is of paramount importance to immunity. Regulated
increases in cytosolic and organellar Ca2+ concentrations in lymphocytes control complex …

Store-operated calcium channels (SOCs) are a major pathway for calcium signaling in
virtually all metozoan cells and serve a wide variety of functions ranging from gene …

Store-operated Ca2+ entry (SOCE) is a ubiquitous Ca2+ signaling pathway that is
evolutionarily conserved across eukaryotes. SOCE is triggered physiologically when the …

Store-operated calcium entry is a central mechanism in cellular calcium signalling and in
maintaining cellular calcium balance. This review traces the history of research on store …

The interplay between Ca 2+ and reactive oxygen species (ROS) signaling pathways is well
established, with reciprocal regulation occurring at a number of subcellular locations. Many …

The essential role of ORAI1 channels in receptor-evoked Ca2+ signaling is well understood,
yet little is known about the physiological activation of the ORAI channel trio natively …

ORAI family channels have emerged as important players in malignant transformation, yet
the way in which they reprogram cancer cells remains elusive. Here we show that the …

The Ca 2+ sensor stromal interacting molecule 1 (STIM1) and the Ca 2+ channel Orai1
mediate the ubiquitous store-operated Ca 2+ entry (SOCE) pathway activated by depletion …

Store-operated calcium channels provide calcium signals to the cytoplasm of a wide variety
of cell types. The basic components of this signaling mechanism include a mechanism for …

Plasma-membrane-localized Orai1 ion channel subunits interacting with ER-localized
STIM1 molecules comprise the major subunit composition responsible for calcium release …