The endoplasmic reticulum (ER) regulates protein synthesis, protein folding and trafficking,
cellular responses to stress and intracellular calcium (Ca 2+) levels. Alterations in Ca 2+ …

Two-dimensional gel electrophoresis has been instrumental in the birth and developments
of proteomics, although it is no longer the exclusive separation tool used in the field of …

The proper functioning of the endoplasmic reticulum (ER) is critical for numerous aspects of
cell physiology. Accordingly, all eukaryotes react rapidly to ER dysfunction through a set of …

The accumulation of misfolded proteins (eg mutant or damaged proteins) triggers cellular
stress responses that protect cells against the toxic buildup of such proteins. However …

Endoplasmic reticulum (ER) stress-induced apoptosis has been implicated in the
development of multiple diseases. However, the in vivo signaling pathways are still not fully …

The chemical properties of copper allow it to take part in many biological functions such as
electron transfer, catalysis, and structural shaping. The ability to cycle between+ 1 and+ 2 …

Sarcoidosis is a complex chronic inflammatory disorder with predominant manifestation in
the lung. In the first genome-wide association study (> 440,000 SNPs) of this disease …

A major unanswered question in biology and medicine is the mechanism by which the
product of the apolipoprotein E ε4 allele, the lipid-binding protein apolipoprotein E4 …

The vascular complications of diabetes mellitus impose a huge burden on the management
of this disease. The higher incidence of cardiovascular complications and the unfavorable …

Aging represents the main risk factor to develop Alzheimer disease (AD) and protein
aggregation constitutes a pathological hallmark thought to be involved in the etiology of this …