Tripartite efflux pumps and the related type 1 secretion systems (T1SSs) in Gram-negative
organisms are diverse in function, energization, and structural organization. They form …

Protein design has come of age, but how will it mature? In the 1980s and the 1990s, the
primary motivation for de novo protein design was to test our understanding of the …

Motivation Coiled coils are protein structural domains that mediate a plethora of biological
interactions, and thus their reliable annotation is crucial for studies of protein structure and …

Motivation Protein–protein interactions are central to all biological processes. One frequently
observed mode of such interactions is the α-helical coiled coil (CC). Thus, an ability to …

The coiled-coil domain-containing (CCDC) proteins have been implicated in a variety of
physiological and pathological processes. Their functional roles vary from their interaction …

Proteins can collapse into compact globules or form expanded, solvent-accessible, coil-like
conformations. Additionally, they can fold into well-defined three-dimensional structures or …

Sex in honeybees, Apis mellifera, is genetically determined by heterozygous versus
homo/hemizygous genotypes involving numerous alleles at the single complementary sex …

Coiled coils are characterized by an arrangement of two or more α-helices into a superhelix
and one of few protein motifs where the sequence-to-structure relationships to a large extent …

Septins are conserved cytoskeletal proteins that regulate cell cortex mechanics. The
mechanisms of their interactions with the plasma membrane remain poorly understood …

We describe de novo-designed α-helical barrels (αHBs) that bind and discriminate between
lipophilic biologically active molecules. αHBs have five or more α-helices arranged around …