Treatments for dry age-related macular degeneration: therapeutic avenues, clinical trials and future directions
Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in
the developed world. The identification of the central role of vascular endothelial growth …
the developed world. The identification of the central role of vascular endothelial growth …
Recent advances in the medicinal chemistry of carbonic anhydrase inhibitors
Abstract Carbonic anhydrase (CA, EC 4.2. 1.1) is an enzyme and a very omnipresent zinc
metalloenzyme which catalyzed the reversible hydration and dehydration of carbon dioxide …
metalloenzyme which catalyzed the reversible hydration and dehydration of carbon dioxide …
Nicotinamide and pyruvate for neuroenhancement in open-angle glaucoma: a phase 2 randomized clinical trial
Importance Open-angle glaucoma may continue to progress despite significant lowering of
intraocular pressure (IOP). Preclinical research has suggested that enhancing mitochondrial …
intraocular pressure (IOP). Preclinical research has suggested that enhancing mitochondrial …
Latanoprost for open-angle glaucoma (UKGTS): a randomised, multicentre, placebo-controlled trial
Background Treatments for open-angle glaucoma aim to prevent vision loss through
lowering of intraocular pressure, but to our knowledge no placebo-controlled trials have …
lowering of intraocular pressure, but to our knowledge no placebo-controlled trials have …
Oxidative stress and reactive oxygen species: a review of their role in ocular disease
For many years, oxidative stress arising from the ubiquitous production of reactive oxygen
species (ROS) has been implicated in the pathogenesis of various eye diseases. While …
species (ROS) has been implicated in the pathogenesis of various eye diseases. While …
Comparative effectiveness of treatments for open-angle glaucoma: a systematic review for the US Preventive Services Task Force
Background: Glaucoma is an acquired degeneration of the optic nerve and a leading cause
of blindness worldwide. Medical and surgical treatments that decrease intraocular pressure …
of blindness worldwide. Medical and surgical treatments that decrease intraocular pressure …
Glaucoma 2.0: neuroprotection, neuroregeneration, neuroenhancement
EE Chang, JL Goldberg - Ophthalmology, 2012 - Elsevier
Glaucoma is a progressive neurodegenerative disease of retinal ganglion cells (RGCs)
associated with characteristic axon degeneration in the optic nerve. Clinically, our only …
associated with characteristic axon degeneration in the optic nerve. Clinically, our only …
Ophthalmic drug discovery: novel targets and mechanisms for retinal diseases and glaucoma
Blindness affects 60 million people worldwide. The leading causes of irreversible blindness
include age-related macular degeneration, retinal vascular diseases and glaucoma. The …
include age-related macular degeneration, retinal vascular diseases and glaucoma. The …
Newer advances in medical management of glaucoma
N Mohan, A Chakrabarti, N Nazm… - Indian journal of …, 2022 - journals.lww.com
The burden of irreversible vision loss from Glaucoma continues to rise. While the disease
pathogenesis is not well understood, intraocular pressure (IOP) is the only modifiable risk …
pathogenesis is not well understood, intraocular pressure (IOP) is the only modifiable risk …
Systematic review and meta-analysis on the efficacy of selective laser trabeculoplasty in open-angle glaucoma
Selective laser trabeculoplasty (SLT) is a relatively new type of laser used in treating open-
angle glaucoma (OAG) and is reported to be equally efficacious to a first-line medication and …
angle glaucoma (OAG) and is reported to be equally efficacious to a first-line medication and …