An overview of JAK/STAT pathways and JAK inhibition in alopecia areata

M Lensing, A Jabbari - Frontiers in immunology, 2022 - frontiersin.org
Alopecia Areata (AA) is a common autoimmune disease characterized by non-scarring hair
loss ranging from patches on the scalp to complete hair loss involving the entire body …

Alopecia areata: a review of disease pathogenesis

F Rajabi, LA Drake, MM Senna… - British Journal of …, 2018 - academic.oup.com
Background Alopecia areata is a disorder that results in nonscarring hair loss. The
psychological impact can be significant, leading to feelings of depression and social …

A virtual memory CD8+ T cell-originated subset causes alopecia areata through innate-like cytotoxicity

J Seok, SD Cho, J Lee, Y Choi, SY Kim, SM Lee… - Nature …, 2023 - nature.com
Virtual memory T (TVM) cells are a T cell subtype with a memory phenotype but no prior
exposure to foreign antigen. Although TVM cells have antiviral and antibacterial functions …

Alopecia areata: animal models illuminate autoimmune pathogenesis and novel immunotherapeutic strategies

A Gilhar, AG Schrum, A Etzioni, H Waldmann… - Autoimmunity reviews, 2016 - Elsevier
One of the most common human autoimmune diseases, alopecia areata (AA), is
characterized by sudden, often persisting and psychologically devastating hair loss. Animal …

Alopecia areata: what's new in epidemiology, pathogenesis, diagnosis, and therapeutic options?

T Dainichi, K Kabashima - Journal of dermatological science, 2017 - Elsevier
Alopecia areata (AA) is a common and stressful disorder that results in hair loss, and
resistant to treatment in some cases. Experimental and clinical evidence suggests that AA is …

Pathomechanisms of immune-mediated alopecia

A Anzai, EHC Wang, EY Lee, V Aoki… - International …, 2019 - academic.oup.com
The hair follicle (HF) is a complex mini-organ that constantly undergoes dynamic cycles of
growth and regression throughout life. While proper progression of the hair cycle requires …

[HTML][HTML] Identification of autoantigen epitopes in alopecia areata

EHC Wang, M Yu, T Breitkopf… - Journal of Investigative …, 2016 - Elsevier
Alopecia areata (AA) is believed to be a cell-mediated autoimmune hair loss disease. Both
CD4 and cytotoxic CD8 T cells (CTLs) are important for the onset and progression of AA …

Innovative strategies for the discovery of new drugs against alopecia areata: taking aim at the immune system

HW Guo, ZM Ye, SQ Chen… - Expert Opinion on Drug …, 2024 - Taylor & Francis
Introduction The autoimmune hair loss condition alopecia areata (AA) exacts a substantial
psychological and socioeconomic toll on patients. Biotechnology companies, dermatology …

Selective expansion of tregs using the IL-2 cytokine antibody complex does not reverse established alopecia areata in C3H/HeJ mice

E Lee, M Kim, YJ Lee - Frontiers in Immunology, 2022 - frontiersin.org
Alopecia areata (AA) is an autoimmune disease mediated by NKG2D-expressing cytotoxic T
lymphocytes destroying hair follicles in the skin. It is one of the most common autoimmune …

A “hair‐raising” history of alopecia areata

D Broadley, KJ McElwee - Experimental dermatology, 2020 - Wiley Online Library
A 3500‐year‐old papyrus from ancient Egypt provides a list of treatments for many diseases
including “bite hair loss,” most likely alopecia areata (AA). The treatment of AA remained …