The SLC22 family contains 13 functionally characterized human plasma membrane proteins
each with 12 predicted α-helical transmembrane domains. The family comprises organic …

Since its discovery, the unique properties of the naturally occurring amino acid, L-
ergothioneine (EGT; 2-mercaptohistidine trimethylbetaine), have intrigued researchers for …

Ergothioneine (ET) is a diet-derived, thiolated derivative of histidine with antioxidant
properties. Although ET is produced only by certain fungi and bacteria, it can be found at …

Primary systemic carnitine deficiency (SCD) is an autosomal recessive disorder caused by
defective cellular carnitine transport. Patients usually present with predominant metabolic or …

Metabolism facilitates the elimination, detoxification and excretion in urine or bile (as
biotransformation products) of a myriad of structurally diverse drugs and other chemicals …

Imazalil (IMZ) is a fungicide recommended by the Chinese ministry of agriculture. However,
recent study was observed high level of IMZ by dietary exposure in pregnant women. To …

OBJECTIVE: The aim of this study was to investigate the association of DLG5 and SLC22A5
gene polymorphisms with the onset of Crohn's disease (CD) in a Malaysian cohort …

The human organic cation/carnitine transporter-2 (hOCTN2; SLC22A5) mediates the cellular
influx of organic cations such as carnitine, which is essential for fatty acid oxidation. Primary …

Precision medicine faces many challenges, including the gap of knowledge between
disease genetics and pharmacogenomics (PGx). Disease genetics interprets the …

Membrane transporters play a critical role in drug response as they provide the targets for
many commonly used drugs and are major determinants of drug absorption, distribution …