Effects of aneuploidy on cell behaviour and function
Aneuploidy, a genomic alternation characterized by deviations in the copy number of
chromosomes, affects organisms from early development through to aging. Although it is a …
chromosomes, affects organisms from early development through to aging. Although it is a …
Human haematopoietic stem cell development: from the embryo to the dish
Haematopoietic stem cells (HSCs) emerge during embryogenesis and give rise to the adult
haematopoietic system. Understanding how early haematopoietic development occurs is of …
haematopoietic system. Understanding how early haematopoietic development occurs is of …
Decoding human fetal liver haematopoiesis
Definitive haematopoiesis in the fetal liver supports self-renewal and differentiation of
haematopoietic stem cells and multipotent progenitors (HSC/MPPs) but remains poorly …
haematopoietic stem cells and multipotent progenitors (HSC/MPPs) but remains poorly …
Blood and immune development in human fetal bone marrow and Down syndrome
Haematopoiesis in the bone marrow (BM) maintains blood and immune cell production
throughout postnatal life. Haematopoiesis first emerges in human BM at 11–12 weeks after …
throughout postnatal life. Haematopoiesis first emerges in human BM at 11–12 weeks after …
The emerging role of GATA transcription factors in development and disease
MHFM Lentjes, HEC Niessen, Y Akiyama… - Expert reviews in …, 2016 - cambridge.org
The GATA family of transcription factors consists of six proteins (GATA1-6) which are
involved in a variety of physiological and pathological processes. GATA1/2/3 are required …
involved in a variety of physiological and pathological processes. GATA1/2/3 are required …
The prenatal origins of cancer
GM Marshall, DR Carter, BB Cheung, T Liu… - Nature Reviews …, 2014 - nature.com
The concept that some childhood malignancies arise from postnatally persistent embryonal
cells has a long history. Recent research has strengthened the links between driver …
cells has a long history. Recent research has strengthened the links between driver …
[HTML][HTML] Identification of a human natural killer cell lineage-restricted progenitor in fetal and adult tissues
VM Renoux, A Zriwil, C Peitzsch, J Michaëlsson… - Immunity, 2015 - cell.com
Natural killer (NK) cells are cytotoxic lymphocytes and play a vital role in controlling viral
infections and cancer. In contrast to B and T lymphopoiesis where cellular and regulatory …
infections and cancer. In contrast to B and T lymphopoiesis where cellular and regulatory …
[HTML][HTML] Transient abnormal myelopoiesis and AML in Down syndrome: an update
N Bhatnagar, L Nizery, O Tunstall, P Vyas… - Current hematologic …, 2016 - Springer
Children with constitutional trisomy 21 (Down syndrome (DS)) have a unique predisposition
to develop myeloid leukaemia of Down syndrome (ML-DS). This disorder is preceded by a …
to develop myeloid leukaemia of Down syndrome (ML-DS). This disorder is preceded by a …
GATA1-mutant clones are frequent and often unsuspected in babies with Down syndrome: identification of a population at risk of leukemia
I Roberts, K Alford, G Hall, G Juban… - Blood, The Journal …, 2013 - ashpublications.org
Transient abnormal myelopoiesis (TAM), a preleukemic disorder unique to neonates with
Down syndrome (DS), may transform to childhood acute myeloid leukemia (ML-DS) …
Down syndrome (DS), may transform to childhood acute myeloid leukemia (ML-DS) …
[HTML][HTML] Single-cell profiling of human megakaryocyte-erythroid progenitors identifies distinct megakaryocyte and erythroid differentiation pathways
Background Recent advances in single-cell techniques have provided the opportunity to
finely dissect cellular heterogeneity within populations previously defined by “bulk” assays …
finely dissect cellular heterogeneity within populations previously defined by “bulk” assays …