Neurodegenerative diseases pose a substantial socioeconomic burden on society.
Unfortunately, the aging world population and lack of effective cures foreshadow a negative …

This review is concerned with the role of fibrillization of the amyloid β (Aβ)-peptide in
Alzheimer's disease (AD). The perspective is that of a physical chemist, and one aim is to …

The NonCovalent Interaction index (NCI) enables identification of attractive and repulsive
noncovalent interactions from promolecular densities in a fast manner. However, the …

Tissue deposition of normally soluble proteins as insoluble amyloid fibrils is associated with
serious diseases including the systemic amyloidoses, maturity onset diabetes, Alzheimer's …

There is mounting evidence that Alzheimer's disease progression and severity are linked to
neuronal membrane damage caused by aggregates of the amyloid-β (A β) peptide …

Structural studies of Alzheimer's amyloid fibrils have revealed information about the structure
at different levels. The amyloid-β peptide has been examined in various solvents and …

The major components of neuritic plaques found in Alzheimer disease (AD) are peptides
known as amyloid β‐peptides (Aβ), which derive from the proteolitic cleavage of the amyloid …

Publisher Summary The chapter discusses the structural analysis of amyloid fibrils by
electron microscopy and X-ray diffraction. A method to isolate amyloid fibrils from tissue was …

Amyloid β-protein (Aβ) assembly into toxic oligomeric and fibrillar structures is a seminal
event in Alzheimer's disease, therefore blocking this process could have significant …

The seven-residue peptide N-acetyl-Lys-Leu-Val-Phe-Phe-Ala-Glu-NH2, called Aβ16-22
and representing residues 16− 22 of the full-length β-amyloid peptide associated with …