Landscape and flux theory of non-equilibrium dynamical systems with application to biology
J Wang - Advances in Physics, 2015 - Taylor & Francis
We present a review of the recently developed landscape and flux theory for non-equilibrium
dynamical systems. We point out that the global natures of the associated dynamics for non …
dynamical systems. We point out that the global natures of the associated dynamics for non …
Unraveling non-genetic heterogeneity in cancer with dynamical models and computational tools
Individual cells within an otherwise genetically homogenous population constantly undergo
fluctuations in their molecular state, giving rise to non-genetic heterogeneity. Such diversity …
fluctuations in their molecular state, giving rise to non-genetic heterogeneity. Such diversity …
MicroRNA-based regulation of epithelial–hybrid–mesenchymal fate determination
Forward and backward transitions between epithelial and mesenchymal phenotypes play
crucial roles in embryonic development and tissue repair. Aberrantly regulated transitions …
crucial roles in embryonic development and tissue repair. Aberrantly regulated transitions …
Modeling the genetic regulation of cancer metabolism: interplay between glycolysis and oxidative phosphorylation
Abnormal metabolism is a hallmark of cancer, yet its regulation remains poorly understood.
Cancer cells were considered to utilize primarily glycolysis for ATP production, referred to as …
Cancer cells were considered to utilize primarily glycolysis for ATP production, referred to as …
An Ovol2-Zeb1 mutual inhibitory circuit governs bidirectional and multi-step transition between epithelial and mesenchymal states
T Hong, K Watanabe, CH Ta… - PLoS computational …, 2015 - journals.plos.org
Reversible epithelial-to-mesenchymal transition (EMT) is central to tissue development,
epithelial stemness, and cancer metastasis. While many regulatory elements have been …
epithelial stemness, and cancer metastasis. While many regulatory elements have been …
Interrogating the topological robustness of gene regulatory circuits by randomization
One of the most important roles of cells is performing their cellular tasks properly for survival.
Cells usually achieve robust functionality, for example, cell-fate decision-making and signal …
Cells usually achieve robust functionality, for example, cell-fate decision-making and signal …
Towards elucidating the connection between epithelial–mesenchymal transitions and stemness
Epithelial cells undergoing epithelial-to-mesenchymal transitions have often been shown to
behave as cancer stem cells, but the precise molecular connection remains elusive. At the …
behave as cancer stem cells, but the precise molecular connection remains elusive. At the …
Jagged–Delta asymmetry in Notch signaling can give rise to a Sender/Receiver hybrid phenotype
Notch signaling pathway mediates cell-fate determination during embryonic development,
wound healing, and tumorigenesis. This pathway is activated when the ligand Delta or the …
wound healing, and tumorigenesis. This pathway is activated when the ligand Delta or the …
[HTML][HTML] OVOL guides the epithelial-hybrid-mesenchymal transition
Metastasis involves multiple cycles of Epithelial-to-Mesenchymal Transition (EMT) and its
reverse-MET. Cells can also undergo partial transitions to attain a hybrid epithelial …
reverse-MET. Cells can also undergo partial transitions to attain a hybrid epithelial …
A possible role for epigenetic feedback regulation in the dynamics of the epithelial–mesenchymal transition (EMT)
The epithelial–mesenchymal transition (EMT) often plays a critical role in cancer metastasis
and chemoresistance, and decoding its dynamics is crucial to design effective therapeutics …
and chemoresistance, and decoding its dynamics is crucial to design effective therapeutics …