Gonadotropin hormone-releasing hormone (GnRH) is the key regulator of the reproductive
axis. Its pulsatile secretion determines the pattern of secretion of the gonadotropins follicle …

Results The kisspeptin system (KISS1/G protein-coupled receptor-54, GPR54) has recently
been addressed as an essential gatekeeper of puberty onset and gonadotropin secretion …

In humans, as in the other mammals, the neuroendocrine control of reproduction is ensured
by the brain-pituitary gonadotropic axis. Multiple internal and environmental cues are …

We evaluated whether the administration of kisspeptin-10 (Kp10) is capable of restoring
gonadal function in hypothyroid male rats. Hypothyroidism was induced with 6-propyl-2 …

Estradiol feedback regulates gonadotropin-releasing hormone (GnRH) neurons and
subsequent luteinizing hormone (LH) release. Estradiol acts via estrogen receptor α (ERα) …

Mammalian reproduction is controlled by the hypothalamic-pituitary-gonadal axis. GnRH
from the hypothalamus regulates synthesis and secretion of gonadotropins, LH and FSH …

The hypothalamic-based kisspeptin-signaling system is a major positive regulator of the
neuroendocrine-reproductive axis in mammals. During the last decade, major advances …

In humans and other mammals, a hallmark of female reproductive function is the capacity to
episodically release fertilizable oocytes under the precise control of a cascade of hormonal …

Background: Hypothyroidism causes ovarian dysfunction and infertility in women, in addition
to being associated with hyperprolactinemia and reduced hypothalamic expression of …

Kisspeptins are key players in the neuroendocrine control of puberty and other reproductive
processes in mammals. Several studies have demonstrated that the KISS/GPR54 system is …