Bone disease in multiple myeloma: biologic and clinical implications

ZS Bernstein, EB Kim, N Raje - Cells, 2022 - mdpi.com
Multiple Myeloma (MM) is a hematologic malignancy characterized by the proliferation of
monoclonal plasma cells localized within the bone marrow. Bone disease with associated …

Pathogenesis and treatment of myeloma-related bone disease

YC Gau, TJ Yeh, CM Hsu, SY Hsiao… - International Journal of …, 2022 - mdpi.com
Multiple myeloma is a hematologic malignancy of plasma cells that causes bone-destructive
lesions and associated skeletal-related events (SREs). The pathogenesis of myeloma …

Targeting chemokine receptor CCR1 as a potential therapeutic approach for multiple myeloma

A Gilchrist, SL Echeverria - Frontiers in Endocrinology, 2022 - frontiersin.org
Multiple myeloma is an incurable plasma B-cell malignancy with 5-year survival rates
approximately 10-30% lower than other hematologic cancers. Treatment options include …

Pain management in patients with multiple myeloma: an update

F Coluzzi, R Rolke, S Mercadante - Cancers, 2019 - mdpi.com
Most patients with multiple myeloma (MM) suffer from chronic pain at every stage of the
natural disease process. This review focuses on the most common causes of chronic pain in …

Extended texture analysis of non-enhanced whole-body MRI image data for response assessment in multiple myeloma patients undergoing systemic therapy

K Ekert, C Hinterleitner, K Baumgartner, J Fritz… - Cancers, 2020 - mdpi.com
Identifying MRI-based radiomics features capable to assess response to systemic treatment
in multiple myeloma (MM) patients. Retrospective analysis of whole-body MR-image data in …

Pathogenesis and treatment of multiple myeloma

P Yang, Y Qu, M Wang, B Chu, W Chen, Y Zheng… - MedComm, 2022 - Wiley Online Library
Multiple myeloma (MM) is the second‐ranking malignancy in hematological tumors. The
pathogenesis of MM is complex with high heterogeneity, and the development of the …

Targeting aberrant DNA methylation in mesenchymal stromal cells as a treatment for myeloma bone disease

A Garcia-Gomez, T Li, C de la Calle-Fabregat… - Nature …, 2021 - nature.com
Multiple myeloma (MM) progression and myeloma-associated bone disease (MBD) are
highly dependent on bone marrow mesenchymal stromal cells (MSCs). MM-MSCs exhibit …

Epidemiology and reporting of osteoporotic vertebral fractures in patients with long-term hospital records based on routine clinical CT imaging

MT Löffler, M Kallweit, E Niederreiter, T Baum… - Osteoporosis …, 2022 - Springer
Osteoporotic vertebral fractures signify an increased risk of future fractures and mortality and
can manifest the diagnosis of osteoporosis. We investigated the prevalence of vertebral …

[HTML][HTML] Multiple myeloma rather than metastatic lung cancer: an unexpected cause of spinal cord compression

CJ Chen, TB Yan, Y Di Liu, Y Wang, X Zhao… - World Journal of …, 2023 - ncbi.nlm.nih.gov
Spinal cord compression caused by cancer metastasis is a medical emergency that should
be managed positively. Both multiple myeloma and lung cancer can lead to metastatic …

An overview of pim kinase as a target in multiple myeloma

Z Liu, Y Zhang, Y Guo, H Wang, R Fu - Cancer Medicine, 2023 - Wiley Online Library
Multiple myeloma (MM) is the second common hematologic malignancy manifesting as a
clonal proliferation of plasma cells in the bone marrow. In recent years, high expression and …