Novel flurbiprofen clubbed oxadiazole derivatives as potential urease inhibitors and their molecular docking study
In this study, twenty eight novel oxadiazole derivatives (5–32) of the marketed available non-
steroidal anti-inflammatory drug (NSAID),(S)-flurbiprofen (1), were synthesized via I2 …
steroidal anti-inflammatory drug (NSAID),(S)-flurbiprofen (1), were synthesized via I2 …
Direct and practical synthesis of primary anilines through iron-catalyzed C–H bond amination
The direct C–H amination of arenes is an important strategy to streamline the discovery and
preparation of functional molecules. Herein, we report an operationally simple arene C–H …
preparation of functional molecules. Herein, we report an operationally simple arene C–H …
Arylpropionic acid-derived NSAIDs: New insights on derivatization, anticancer activity and potential mechanism of action
NSAIDs displayed chemopreventive and anticancer effects against several types of cancers.
Moreover, combination of NSAIDs with anticancer agents resulted in enhanced anticancer …
Moreover, combination of NSAIDs with anticancer agents resulted in enhanced anticancer …
Design and synthesis of novel (S)-Naproxen hydrazide-hydrazones as potent VEGFR-2 inhibitors and their evaluation in vitro/in vivo breast cancer models
Naproxen is a common non-steroidal anti-inflammatory drug, which is the most usually used
propionic acid derivative for the treatment of many types of diseases. In this study, a series of …
propionic acid derivative for the treatment of many types of diseases. In this study, a series of …
Synthesis of novel diflunisal hydrazide–hydrazones as anti-hepatitis C virus agents and hepatocellular carcinoma inhibitors
S Şenkardeş, N Kaushik-Basu, I Durmaz… - European journal of …, 2016 - Elsevier
Highlights•We synthesized new diflunisal hydrazide–hydrazones.•We investigated their
activity against hepatitis C virus (HCV).•Some compounds exhibited strong inhibition against …
activity against hepatitis C virus (HCV).•Some compounds exhibited strong inhibition against …
Recent advancements in NS5B inhibitors (2011-2021): Structural insights, SAR studies and clinical status
About 130–150 million people worldwide are chronically infected with the hepatitis C virus
(HCV), and this infection can lead to serious liver problems such as cirrhosis, hepatocellular …
(HCV), and this infection can lead to serious liver problems such as cirrhosis, hepatocellular …
Design, synthesis, and anticancer evaluation of novel tetracaine hydrazide-hydrazones
Mİ Han, N Imamoglu - ACS omega, 2023 - ACS Publications
Tetracaine is an ester derivative used as a local anesthetic molecule. In this study, a series
of novel Tetracaine derivatives bearing hydrazide-hydrazone moiety were designed …
of novel Tetracaine derivatives bearing hydrazide-hydrazone moiety were designed …
Design, synthesis and anticancer activity studies of novel 4-butylaminophenyl hydrazide-hydrazones as apoptotic inducers
In this study, a series of the novel Tetracaine derivatives bearing hydrazide-hydrazone
moiety were designed, synthesized, and evaluated for anticancer activity. The structures of …
moiety were designed, synthesized, and evaluated for anticancer activity. The structures of …
Chiral lactic hydrazone derivatives as potential bioactive antibacterial agents: Synthesis, spectroscopic, structural and molecular docking studies
A series of novel chiral lactic-hydrazone derivatives were synthesized by condensation of
(S)-lactic acid hydrazide with salicylaldehyde derivatives and characterized by elemental …
(S)-lactic acid hydrazide with salicylaldehyde derivatives and characterized by elemental …
Synthesis of tolmetin hydrazide–hydrazones and discovery of a potent apoptosis inducer in colon cancer cells
ŞG Küçükgüzel, D Koç, P Çıkla‐Süzgün… - Archiv Der …, 2015 - Wiley Online Library
Tolmetin hydrazide and a novel series of tolmetin hydrazide–hydrazones 4a–l were
synthesized in this study. The structures of the new compounds were determined by spectral …
synthesized in this study. The structures of the new compounds were determined by spectral …