The emergence of carbapenem-resistant Gram-negative pathogens poses a serious threat
to public health worldwide. In particular, the increasing prevalence of carbapenem-resistant …

Carbapenemases are β-lactamases with versatile hydrolytic capacities. They have the ability
to hydrolyze penicillins, cephalosporins, monobactams, and carbapenems. Bacteria …

Carbapenems, once considered the last line of defense against of serious infections with
Enterobacteriaceae, are threatened with extinction. The increasing isolation of carbapenem …

The emergence and rapid spread of carbapenemases in Enterobacteriaceae,
Pseudomonas and Acinetobacter (EPA) species is becoming a major public health crisis …

Carbapenems, such as imipenem and meropenem, are most often used to treat infections
caused by enterobacteria that produce extended-spectrum β-lactamases, and the …

Purpose Carbapenems are considered the most efficient antibiotic used in the treatment of
nosocomial infections. Carbapenem-resistant Gram-negative rods are becoming a serious …

The first outbreak of carbapenem-resistant Klebsiella pneumoniae isolates producing the
plasmid-encoded carbapenem-hydrolyzing oxacillinase OXA-48 is reported. The 39 isolates …

The fight against infectious diseases is probably one of the greatest public health challenges
faced by our society, especially with the emergence of carbapenem-resistant gram …

Gram-negative bacteria, especially Enterobacterales, have emerged as major players in
antimicrobial resistance worldwide. Resistance may affect all major classes of anti-gram …

Extended‐spectrum β‐lactamases (ESBLs) are usually plasmid‐mediated enzymes that
confer resistance to a broad range of β‐lactams. Initially, resistance to third‐generation …