Epidemiological data indicate a constant worldwide increase in cancer mortality, although
the age of onset is increasing. Recent accumulation of genomic data on human cancer via …

The onset of lipid peroxidation within cellular membranes is associated with changes in their
physiochemical properties and with the impairment of enzymatic functions located in the …

Reactive carbonyl compounds (RCCs) formed during lipid peroxidation and sugar
glycoxidation, namely Advanced lipid peroxidation end products (ALEs) and Advanced …

There is increasing evidence that aldehydes generated endogenously during the
degradation process of biological molecules are involved in many of the pathophysiologies …

Hydroxy-2-nonenal (HNE) is one of the most studied products of phospholipid peroxidation,
owing to its reactivity and cytotoxicity. It can be formed by several radical-dependent …

A comprehensive focus on 4‐hydroxynonenal (HNE) as candidate molecule in a variety of
pathophysiological conditions occurring in humans is here provided. Despite an active, now …

Lipids can go through lipid peroxidation, an endogenous chain reaction that consists in the
oxidative degradation of lipids leading to the generation of a wide variety of highly reactive …

Loss of bone mass with advancing age in mice is because of decreased osteoblast number
and is associated with increased oxidative stress and decreased canonical Wnt signaling …

Cardiotoxicity is one of the major side effects encountered during cancer chemotherapy with
doxorubicin (DOX) and other anthracyclines. Previous studies have shown that oxidative …

There is increasing evidence that aging is affected by biological (circadian) clocks-the
internal mechanisms that coordinate daily changes in gene expression, physiological …