Lysosomal acid lipase (LAL) is the sole enzyme known to degrade neutral lipids in the
lysosome. Mutations in the LAL-encoding LIPA gene lead to rare lysosomal lipid storage …

Non-alcoholic fatty liver disease (NAFLD), characterized by the accumulation of excessive
intrahepatic fat, is a leading metabolic disorder also considered as the hepatic manifestation …

Lysosomal acid lipase (LAL), encoded by the gene LIPA, is the sole neutral lipid hydrolase
in lysosomes, responsible for cleavage of cholesteryl esters and triglycerides into their …

The human LIPA gene encodes for the enzyme lysosomal acid lipase, which hydrolyzes
cholesteryl ester and triacylglycerol. Lysosomal acid lipase deficiency results in Wolman …

Lysosomal acid lipase (LAL) is a lysosomal enzyme essential for the degradation of
cholesteryl esters through the endocytic pathway. Deficiency of the LAL enzyme encoded by …

The multiple functions of the lysosome, including degradation, nutrient sensing, signaling,
and gene regulation, enable the lysosome to regulate lipid metabolism at different levels. In …

Lysosomal acid lipase (LAL), encoded by the LIPA gene, is the only known acidic lipase that
hydrolyzes cholesteryl ester (CE) and triglycerides (TGs) in lysosomes. These lipids …

Background Genome-wide association studies revealed a robust association between
genetic variants in the LIPA (lysosomal acid lipase) gene and coronary artery diseases …