An oncofetal and developmental perspective on testicular germ cell cancer
MA Rijlaarsdam, LHJ Looijenga - Seminars in cancer biology, 2014 - Elsevier
Germ cell tumors (GCTs) represent a diverse group of tumors presumably originating from
(early fetal) developing germ cells. Most frequent are the testicular germ cell cancers …
(early fetal) developing germ cells. Most frequent are the testicular germ cell cancers …
Molecular biology of testicular germ cell tumors
Testicular germ cell tumors (TGCTs) are the most common solid tumors in young adult men.
They constitute a unique pathology because of their embryonic and germ origin and their …
They constitute a unique pathology because of their embryonic and germ origin and their …
NR5A2 gene affects the overall survival of LUAD patients by regulating the activity of CSCs through SNP pathway by OCLR algorithm and immune score
L Wu, X Chen, Q Zeng, Z Lai, Z Fan, X Ruan, X Li… - Heliyon, 2024 - cell.com
Abstract Objective Differentially expressed genes (DEGs) in lung adenocarcinoma (LUAD)
tumor stem cells were screened, and the biological characteristics of NR5A2 gene were …
tumor stem cells were screened, and the biological characteristics of NR5A2 gene were …
STELLA facilitates differentiation of germ cell and endodermal lineages of human embryonic stem cells
P Wongtrakoongate, M Jones, PJ Gokhale… - PloS one, 2013 - journals.plos.org
Stella is a developmentally regulated gene highly expressed in mouse embryonic stem (ES)
cells and in primordial germ cells (PGCs). In human, the gene encoding the STELLA …
cells and in primordial germ cells (PGCs). In human, the gene encoding the STELLA …
Identification of novel fusion genes in testicular germ cell tumors
Testicular germ cell tumors (TGCT) are the most frequently diagnosed solid tumors in young
men ages 15 to 44 years. Embryonal carcinomas (EC) comprise a subset of TGCTs that …
men ages 15 to 44 years. Embryonal carcinomas (EC) comprise a subset of TGCTs that …
Alternative splicing events and splicing factors are prognostic in adrenocortical carcinoma
J Lv, Y He, L Li, Z Wang - Frontiers in genetics, 2020 - frontiersin.org
Alternative splicing is involved in the pathogenesis of human diseases, including cancer.
Here, we investigated the potential application of alternative splicing events (ASEs) and …
Here, we investigated the potential application of alternative splicing events (ASEs) and …
Aza-deoxycytidine induces apoptosis or differentiation via DNMT3B and targets embryonal carcinoma cells but not their differentiated derivatives
P Wongtrakoongate, J Li, PW Andrews - British journal of cancer, 2014 - nature.com
Background: Teratocarcinoma is a malignant male germ cell tumour, which contains stem
cells and differentiated cancer tissues. DNMT3B has been shown to be highly expressed in …
cells and differentiated cancer tissues. DNMT3B has been shown to be highly expressed in …
An integrated analysis of the SOX2 microRNA response program in human pluripotent and nullipotent stem cell lines
SF Vencken, P Sethupathy, G Blackshields, C Spillane… - BMC genomics, 2014 - Springer
Background SOX2 is a core component of the transcriptional network responsible for
maintaining embryonal carcinoma cells (ECCs) in a pluripotent, undifferentiated state of self …
maintaining embryonal carcinoma cells (ECCs) in a pluripotent, undifferentiated state of self …
[HTML][HTML] DNA microarray reveals ZNF195 and SBF1 are potential biomarkers for gemcitabine sensitivity in head and neck squamous cell carcinoma cell lines
MH Zhu, SL Ji, CY Zhang, L Cui, L Xiong… - International journal of …, 2014 - ncbi.nlm.nih.gov
Gemcitabine is a potential chemotherapy drug for treatment of head and neck squamous cell
carcinoma (HNSCC), however, the poor or partial response of HNSCC patients to …
carcinoma (HNSCC), however, the poor or partial response of HNSCC patients to …
Frequent copy number gains of SLC2A3 and ETV1 in testicular embryonal carcinomas
AM Hoff, SM Kraggerud, S Alagaratnam… - Endocrine-Related …, 2020 - erc.bioscientifica.com
Testicular germ cell tumours (TGCTs) appear as different histological subtypes, or mixtures
of these. They show similar, multiple DNA copy number changes, where gain of 12p is …
of these. They show similar, multiple DNA copy number changes, where gain of 12p is …