Disordered fat storage and mobilization in the pathogenesis of insulin resistance and type 2 diabetes

GF Lewis, A Carpentier, K Adeli, A Giacca - Endocrine reviews, 2002 - academic.oup.com
The primary genetic, environmental, and metabolic factors responsible for causing insulin
resistance and pancreatic β-cell failure and the precise sequence of events leading to the …

Why do omega-3 fatty acids lower serum triglycerides?

WS Harris, D Bulchandani - Current opinion in lipidology, 2006 - journals.lww.com
Why do omega-3 fatty acids lower serum triglycerides? : Current Opinion in Lipidology Why do
omega-3 fatty acids lower serum triglycerides? : Current Opinion in Lipidology Log in or …

Strategies, models and biomarkers in experimental non-alcoholic fatty liver disease research

J Willebrords, IVA Pereira, M Maes, SC Yanguas… - Progress in lipid …, 2015 - Elsevier
Non-alcoholic fatty liver disease encompasses a spectrum of liver diseases, including
simple steatosis, steatohepatitis, liver fibrosis and cirrhosis and hepatocellular carcinoma …

Lipid and lipoprotein dysregulation in insulin resistant states

RK Avramoglu, H Basciano, K Adeli - Clinica chimica acta, 2006 - Elsevier
Insulin resistant states are commonly associated with an atherogenic dyslipidemia that
contributes to significantly higher risk of atherosclerosis and cardiovascular disease. Indeed …

Lipid peroxidation and oxidant stress regulate hepatic apolipoprotein B degradation and VLDL production

M Pan, AI Cederbaum, YL Zhang… - The Journal of …, 2004 - Am Soc Clin Investig
How ω-3 and ω-6 polyunsaturated fatty acids (PUFAs) lower plasma lipid levels is
incompletely understood. We previously showed that marine ω-3 PUFAs (docosahexaenoic …

Methods of reducing the risk of a cardiovascular event in a subject on statin therapy

P Soni - US Patent 9,610,272, 2017 - Google Patents
In various embodiments, the present invention provides methods of reducing the risk of a
cardiovascular event in a subject on statin therapy and, in particular, a method of reducing …

Omacor in familial combined hyperlipidemia: effects on lipids and low density lipoprotein subclasses

L Calabresi, D Donati, F Pazzucconi, CR Sirtori… - Atherosclerosis, 2000 - Elsevier
Elevations of plasma cholesterol and/or triglycerides, and the prevalence of small, dense
LDL particles remarkably increase coronary risk in patients with familial combined …

Mechanisms of hepatic very low-density lipoprotein overproduction in insulin resistance

K Adeli, C Taghibiglou, SC Van Iderstine… - Trends in cardiovascular …, 2001 - Elsevier
An important complication of insulin-resistant states, such as obesity and type 2 diabetes, is
an atherogenic dyslipidemia profile characterized by hypertriglyceridemia, low plasma high …

High fat feeding induces hepatic fatty acid elongation in mice

MH Oosterveer, TH van Dijk, UJF Tietge, T Boer… - PloS one, 2009 - journals.plos.org
Background High-fat diets promote hepatic lipid accumulation. Paradoxically, these diets
also induce lipogenic gene expression in rodent liver. Whether high expression of these …

Stable pharmaceutical composition and methods of using same

M Manku - US Patent 8,298,554, 2012 - Google Patents
US8298554B2 - Stable pharmaceutical composition and methods of using same - Google
Patents US8298554B2 - Stable pharmaceutical composition and methods of using same …