The peroxisome proliferator-activated receptor (PPAR) family includes three transcription
factors: PPARα, PPARβ/δ, and PPARγ. PPAR are nuclear receptors activated by oxidised …

Lipid and immune pathways are crucial in the pathophysiology of metabolic and
cardiovascular disease. Arachidonic acid (AA) and its derivatives link nutrient metabolism to …

Controlled immune responses to infection and injury involve complex molecular signalling
networks with coordinated and often opposing actions. Eicosanoids and related bioactive …

Protein lipoxidation refers to the modification by electrophilic lipid oxidation products to form
covalent adducts, which for many years has been considered as a deleterious consequence …

Unsaturated fatty acids are metabolized to reactive products that can act as pro-or anti-
inflammatory signaling mediators. Electrophilic fatty acid species, including nitro-and oxo …

Extra virgin olive oil (EVOO) and olives, key sources of unsaturated fatty acids in the
Mediterranean diet, provide health benefits to humans. Nitric oxide (• NO) and nitrite (NO2−) …

A gap in our understanding of the beneficial systemic responses to dietary constituents
nitrate (NO 3−), nitrite (NO 2−) and conjugated linoleic acid (cLA) is the identification of the …

Nitro fatty acids (NFAs) are endogenously generated lipid mediators deriving from reactions
of unsaturated electrophilic fatty acids with reactive nitrogen species. Furthermore …

The oxidation and nitration of unsaturated fatty acids transforms cell membrane and
lipoprotein constituents into mediators that regulate signal transduction. The formation of 9 …

Macrophages are central to essential physiological processes including the regulation of
innate and adaptive immunity, but they are also central to a number of inflammatory disease …