MBD5 and MBD6 couple DNA methylation to gene silencing through the J-domain protein SILENZIO
DNA methylation is associated with transcriptional repression of eukaryotic genes and
transposons, but the downstream mechanism of gene silencing is largely unknown. Here …
transposons, but the downstream mechanism of gene silencing is largely unknown. Here …
Epigenetic gene regulation in plants and its potential applications in crop improvement
H Zhang, JK Zhu - Nature Reviews Molecular Cell Biology, 2024 - nature.com
DNA methylation, also known as 5-methylcytosine, is an epigenetic modification that has
crucial functions in plant growth, development and adaptation. The cellular DNA methylation …
crucial functions in plant growth, development and adaptation. The cellular DNA methylation …
DNA methylation readers in plants
D Grimanelli, M Ingouff - Journal of Molecular Biology, 2020 - Elsevier
In plants, DNA methylation occurs in distinct sequence contexts, including CG, CHG, and
CHH. Thus, plants have developed a surprisingly diverse set of DNA methylation readers to …
CHH. Thus, plants have developed a surprisingly diverse set of DNA methylation readers to …
Locus-specific control of the de novo DNA methylation pathway in Arabidopsis by the CLASSY family
M Zhou, AMS Palanca, JA Law - Nature genetics, 2018 - nature.com
DNA methylation is essential for gene regulation, transposon silencing and imprinting.
Although the generation of specific DNA methylation patterns is critical for these processes …
Although the generation of specific DNA methylation patterns is critical for these processes …
The CLASSY family controls tissue-specific DNA methylation patterns in Arabidopsis
DNA methylation shapes the epigenetic landscape of the genome, plays critical roles in
regulating gene expression, and ensures transposon silencing. As is evidenced by the …
regulating gene expression, and ensures transposon silencing. As is evidenced by the …
ACD15, ACD21, and SLN regulate the accumulation and mobility of MBD6 to silence genes and transposable elements
BA Boone, L Ichino, S Wang, J Gardiner, J Yun… - Science …, 2023 - science.org
DNA methylation mediates silencing of transposable elements and genes in part via
recruitment of the Arabidopsis MBD5/6 complex, which contains the methyl-CpG binding …
recruitment of the Arabidopsis MBD5/6 complex, which contains the methyl-CpG binding …
A methylated‐DNA‐binding complex required for plant development mediates transcriptional activation of promoter methylated genes
QQ Zhao, RN Lin, L Li, S Chen… - Journal of integrative plant …, 2019 - Wiley Online Library
Although the mechanism of DNA methylation‐mediated gene silencing is extensively
studied, relatively little is known about how promoter methylated genes are protected from …
studied, relatively little is known about how promoter methylated genes are protected from …
Multiplex CRISPR-Cas9 editing of DNA methyltransferases in rice uncovers a class of non-CG methylation specific for GC-rich regions
DNA methylation in the non-CG context is widespread in the plant kingdom and abundant in
mammalian tissues such as the brain and pluripotent cells. Non-CG methylation in …
mammalian tissues such as the brain and pluripotent cells. Non-CG methylation in …
The epigenetic machinery in the life cycle and pharmacoepigenetics
R Cacabelos, I Tellado, P Cacabelos - Pharmacoepigenetics, 2019 - Elsevier
Epigenetics is a discipline that studies potentially reversible heritable changes in gene
expression with no structural modifications in the DNA sequence. The epigenetic machinery …
expression with no structural modifications in the DNA sequence. The epigenetic machinery …
Family-wide characterization of methylated DNA binding ability of arabidopsis MBDs
Z Wu, S Chen, M Zhou, L Jia, Z Li, X Zhang… - Journal of Molecular …, 2022 - Elsevier
Abstract 13 MBD-containing genes (AtMBD1-13) have been identified in Arabidopsis
thaliana so far, however, their DNA binding ability is still controversial. Here, we …
thaliana so far, however, their DNA binding ability is still controversial. Here, we …