MBD5 and MBD6 couple DNA methylation to gene silencing through the J-domain protein SILENZIO

L Ichino, BA Boone, L Strauskulage, CJ Harris, G Kaur… - Science, 2021 - science.org
DNA methylation is associated with transcriptional repression of eukaryotic genes and
transposons, but the downstream mechanism of gene silencing is largely unknown. Here …

Epigenetic gene regulation in plants and its potential applications in crop improvement

H Zhang, JK Zhu - Nature Reviews Molecular Cell Biology, 2024 - nature.com
DNA methylation, also known as 5-methylcytosine, is an epigenetic modification that has
crucial functions in plant growth, development and adaptation. The cellular DNA methylation …

DNA methylation readers in plants

D Grimanelli, M Ingouff - Journal of Molecular Biology, 2020 - Elsevier
In plants, DNA methylation occurs in distinct sequence contexts, including CG, CHG, and
CHH. Thus, plants have developed a surprisingly diverse set of DNA methylation readers to …

Locus-specific control of the de novo DNA methylation pathway in Arabidopsis by the CLASSY family

M Zhou, AMS Palanca, JA Law - Nature genetics, 2018 - nature.com
DNA methylation is essential for gene regulation, transposon silencing and imprinting.
Although the generation of specific DNA methylation patterns is critical for these processes …

The CLASSY family controls tissue-specific DNA methylation patterns in Arabidopsis

M Zhou, C Coruh, G Xu, LM Martins… - Nature …, 2022 - nature.com
DNA methylation shapes the epigenetic landscape of the genome, plays critical roles in
regulating gene expression, and ensures transposon silencing. As is evidenced by the …

ACD15, ACD21, and SLN regulate the accumulation and mobility of MBD6 to silence genes and transposable elements

BA Boone, L Ichino, S Wang, J Gardiner, J Yun… - Science …, 2023 - science.org
DNA methylation mediates silencing of transposable elements and genes in part via
recruitment of the Arabidopsis MBD5/6 complex, which contains the methyl-CpG binding …

A methylated‐DNA‐binding complex required for plant development mediates transcriptional activation of promoter methylated genes

QQ Zhao, RN Lin, L Li, S Chen… - Journal of integrative plant …, 2019 - Wiley Online Library
Although the mechanism of DNA methylation‐mediated gene silencing is extensively
studied, relatively little is known about how promoter methylated genes are protected from …

Multiplex CRISPR-Cas9 editing of DNA methyltransferases in rice uncovers a class of non-CG methylation specific for GC-rich regions

D Hu, Y Yu, C Wang, Y Long, Y Liu, L Feng, D Lu… - The Plant …, 2021 - academic.oup.com
DNA methylation in the non-CG context is widespread in the plant kingdom and abundant in
mammalian tissues such as the brain and pluripotent cells. Non-CG methylation in …

The epigenetic machinery in the life cycle and pharmacoepigenetics

R Cacabelos, I Tellado, P Cacabelos - Pharmacoepigenetics, 2019 - Elsevier
Epigenetics is a discipline that studies potentially reversible heritable changes in gene
expression with no structural modifications in the DNA sequence. The epigenetic machinery …

Family-wide characterization of methylated DNA binding ability of arabidopsis MBDs

Z Wu, S Chen, M Zhou, L Jia, Z Li, X Zhang… - Journal of Molecular …, 2022 - Elsevier
Abstract 13 MBD-containing genes (AtMBD1-13) have been identified in Arabidopsis
thaliana so far, however, their DNA binding ability is still controversial. Here, we …