Peroxisomes are often dismissed as the cellular hoi polloi, relegated to cleaning up reactive
oxygen chemical debris discarded by other organelles. However, their functions extend far …

In recent decades, the role of the peroxisome in physiology and disease conditions has
become increasingly important. Together with the mitochondria and other cellular …

Human peroxisome biogenesis disorders (PBDs) are a heterogeneous group of autosomal
recessive disorders comprised of two clinically distinct subtypes: the Zellweger syndrome …

Almost a century has passed since Knoop performed his classical feeding experiments that
led him to propose the principle of fl-oxidation for the degradation of fatty acids. After …

Peroxisomes perform essential functions in lipid metabolism, including fatty acid oxidation
and plasmalogen synthesis. Here, we describe a role for peroxisomal lipid metabolism in …

Rhizomelic chondrodysplasia punctata (RCDP) is a rare autosomal recessive phenotype
that comprises complementation group 11 of the peroxisome biogenesis disorders (PBD) …

The innate immune response is critical for animal homeostasis and is conserved from
invertebrates to vertebrates. This response depends on specialized cells that recognize …

The removal of damaged or superfluous organelles from the cytosol by selective autophagy
is required to maintain organelle function, quality control and overall cellular homeostasis …

The mechanism of translocation of peroxisomal proteins from the cytoplasm into the matrix is
largely unknown. We have been studying this problem in yeast. We show that the …

PEX19 is a chaperone and import receptor for newly synthesized, class I peroxisomal
membrane proteins (PMPs). PEX19 binds these PMPs in the cytoplasm and delivers them to …