The blood-brain barrier: Physiology and strategies for drug delivery

R Pandit, L Chen, J Götz - Advanced drug delivery reviews, 2020 - Elsevier
The blood-brain barrier (BBB) is a dynamic structure that functions as a gatekeeper,
reflecting the unique requirements of the brain. In this review, following a brief historical …

Ultrasound-mediated nano drug delivery for treating cancer: Fundamental physics to future directions

FM Kashkooli, A Jakhmola, TK Hornsby… - Journal of Controlled …, 2023 - Elsevier
The application of biocompatible nanocarriers in medicine has provided several benefits
over conventional treatment methods. However, achieving high treatment efficacy and deep …

[HTML][HTML] Ultrasound neuromodulation: a review of results, mechanisms and safety

J Blackmore, S Shrivastava, J Sallet, CR Butler… - Ultrasound in medicine …, 2019 - Elsevier
Ultrasonic neuromodulation is a rapidly growing field, in which low-intensity ultrasound (US)
is delivered to nervous system tissue, resulting in transient modulation of neural activity. This …

Ultrasound-mediated blood–brain barrier opening: An effective drug delivery system for theranostics of brain diseases

J Wang, Z Li, M Pan, M Fiaz, Y Hao, Y Yan… - Advanced Drug Delivery …, 2022 - Elsevier
Blood-brain barrier (BBB) remains a significant obstacle to drug therapy for brain diseases.
Focused ultrasound (FUS) combined with microbubbles (MBs) can locally and transiently …

Opening doors with ultrasound and microbubbles: Beating biological barriers to promote drug delivery

J Deprez, G Lajoinie, Y Engelen, SC De Smedt… - Advanced drug delivery …, 2021 - Elsevier
Apart from its clinical use in imaging, ultrasound has been thoroughly investigated as a tool
to enhance drug delivery in a wide variety of applications. Therapeutic ultrasound, as such …

[HTML][HTML] Nanoparticle-assisted ultrasound: A special focus on sonodynamic therapy against cancer

G Canavese, A Ancona, L Racca, M Canta… - Chemical Engineering …, 2018 - Elsevier
At present, ultrasound radiation is broadly employed in medicine for both diagnostic and
therapeutic purposes at various frequencies and intensities. In this review article, we focus …

Ultrasonic neuromodulation causes widespread cortical activation via an indirect auditory mechanism

T Sato, MG Shapiro, DY Tsao - Neuron, 2018 - cell.com
Ultrasound has received widespread attention as an emerging technology for targeted, non-
invasive neuromodulation based on its ability to evoke electrophysiological and motor …

Modern methods for delivery of drugs across the blood–brain barrier

Y Chen, L Liu - Advanced drug delivery reviews, 2012 - Elsevier
The blood–brain barrier (BBB) is a highly regulated and efficient barrier that provides a
sanctuary to the brain. It is designed to regulate brain homeostasis and to permit selective …

Evolving drug delivery strategies to overcome the blood brain barrier

DS Hersh, AS Wadajkar, NB Roberts… - Current …, 2016 - ingentaconnect.com
The blood-brain barrier (BBB) poses a unique challenge for drug delivery to the central
nervous system (CNS). The BBB consists of a continuous layer of specialized endothelial …

Engineering patient-specific cancer immunotherapies

L Scheetz, KS Park, Q Li, PR Lowenstein… - Nature biomedical …, 2019 - nature.com
Research into the immunological processes implicated in cancer has yielded a basis for the
range of immunotherapies that are now considered the fourth pillar of cancer treatment …