Since the incidence of the metabolic syndrome is on the rise in the western world, its
coherence to cancer is becoming more apparent. In this review we discuss the different …

We review a large volume of literature concerning mathematical models of cancer therapy,
oriented towards optimization of treatment protocols. The review, although partly …

Cigarette-smoke (CS) exposure and aging are the leading causes of chronic obstructive
pulmonary disease (COPD)-emphysema development, although the molecular mechanism …

p53 is known as the guardian of the genome and plays various roles in DNA damage and
cancer suppression. The p53 gene was found to express multiple p53 splice variants …

Elevated expression of chemokine receptors in tumors has been reported in many instances
and is related to a number of survival advantages for tumor cells including abnormal …

The role of viral hemorrhagic septicemia virus (VHSV) NV gene in nuclear factor-κB (NF-κB)
activation was investigated. Epithelioma papulosum cyprini (EPC) cells pre-treated with …

Background Ataxia telangiectasia mutated (ATM) is a detector of double-strand breaks
(DSBs) and a crucial component of the DNA damage response (DDR) along with p53 and …

Intracellular processes are cascades of biochemical reactions, triggered in response to
various types of stimuli. Mathematical models describing their dynamics have become …

Marine organisms possess a series of cellular strategies to counteract the negative effects of
toxic compounds, including the massive reorganization of gene expression networks. Here …

The pain induced by local acute inflammation results in mild to severe discomfort, in addition
to the possibility of physiological dysfunction and psychiatric disorders, such as sleep …