Homo-harringtonine (HHT) is highly effective against SARS-CoV-2-A potential first-line defense in future coronavirus epidemics
HJ Wen, HJ Ma, GX Zhong, A Ding… - National Science …, 2024 - academic.oup.com
As COVID-19 is the third coronavirus epidemic in this century, it would be desirable to have
a treatment scheme in anticipation of a fourth one. We here present a scheme that could …
a treatment scheme in anticipation of a fourth one. We here present a scheme that could …
Multi‐Organ Spread and Intra‐Host Diversity of SARS‐CoV‐2 Support Viral Persistence, Adaptation, and a Mechanism That Increases Evolvability
JM Manrique, S Maffia‐Bizzozero… - Journal of Medical …, 2024 - Wiley Online Library
Intra‐host diversity is an intricate phenomenon related to immune evasion, antiviral
resistance, and evolutionary leaps along transmission chains. SARS‐CoV‐2 intra‐host …
resistance, and evolutionary leaps along transmission chains. SARS‐CoV‐2 intra‐host …
Sequence signatures within the genome of SARS-CoV-2 can be used to predict host source
J Rudar, P Kruczkiewicz, O Vernygora… - Microbiology …, 2024 - Am Soc Microbiol
We conducted an in silico analysis to better understand the potential factors impacting host
adaptation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in white …
adaptation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in white …
[HTML][HTML] Modeling viral evolution: A novel SIRSVIDE framework with application to SARS-CoV-2 dynamics
Understanding evolutionary trends in emerging viruses, such as severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), is crucial for effective public health management …
syndrome coronavirus 2 (SARS-CoV-2), is crucial for effective public health management …
The paradox of extremely fast evolution driven by genetic drift in multi-copy gene systems
X Wang, Y Ruan, L Zhang, X Chen, Z Shi, H Wang… - bioRxiv, 2023 - biorxiv.org
Genetic drift should be any random forces that change gene frequency stochastically. While
the conventions including the WF (Wright-Fisher) model are about sampling errors between …
the conventions including the WF (Wright-Fisher) model are about sampling errors between …
The integrated WF-Haldane (WFH) model of genetic drift resolving the many paradoxes of molecular evolution
Genetic drift, the random changes in frequencies of neutral variants, is the fundamental force
of molecular evolution. Under-estimation of genetic drift is a major cause of mis-conclusions …
of molecular evolution. Under-estimation of genetic drift is a major cause of mis-conclusions …
Applying Multivariate Decision Trees to Visualize, Select Features, and Gain Insights into Biodiversity Genomics Datasets
J Rudar - 2024 - atrium.lib.uoguelph.ca
Advancements of sequencing technology has provided an unprecedented window into a
previously hidden world of biological diversity. This technology has allowed for the …
previously hidden world of biological diversity. This technology has allowed for the …
Tradeoffs between proliferation and transmission in virus evolution–insights from evolutionary and functional analyses of SARS-CoV-2
JH Tai, DC Lee, HF Lin, TL Chao, Y Ruan, YW Cheng… - 2024 - researchsquare.com
To be successful a virus must maintain high between-host transmissibility while also
effectively adapting within hosts. The impact of these potentially conflicting demands on viral …
effectively adapting within hosts. The impact of these potentially conflicting demands on viral …
Genome surveillance of SARS-CoV-2 variants in Wuhan in June 2023
Y Yan, Z Pan, L Mao, P Niu, F Lu, Y Li, Z Li - 2024 - researchsquare.com
The COVID-19 pandemic caused by SARS-CoV-2 has had a significant impact on global
social and economic activities. The continuous emergence of new SARS-CoV-2 variants has …
social and economic activities. The continuous emergence of new SARS-CoV-2 variants has …