Polyploidy, or the duplication of entire genomes, has been observed in prokaryotic and
eukaryotic organisms, and in somatic and germ cells. The consequences of polyploidization …

Aneuploidy, or imbalanced chromosome number, has profound effects on eukaryotic cells.
In humans, aneuploidy is associated with various pathologies, including cancer, which …

Reactive oxygen species (ROS) are generated and consumed in living organism for normal
metabolism. Paradoxically, the overproduction and/or mismanagement of ROS have been …

Aneuploidy, a genomic alternation characterized by deviations in the copy number of
chromosomes, affects organisms from early development through to aging. Although it is a …

Aneuploidy, chromosome stoichiometry that deviates from exact multiples of the haploid
compliment of an organism, exists in eukaryotic microbes, several normal human tissues …

Male infertility is a multifactorial complex disease with highly heterogeneous phenotypic
representation and in at least 15% of cases, this condition is related to known genetic …

Aneuploidy is a very rare and tissue‐specific event in normal conditions, occurring in a low
number of brain and liver cells. Its frequency increases in age‐related disorders and is one …

Males are XY and females are XX in most mammalian species. Other species such as birds
have a different sex chromosome make-up: ZZ in males and ZW in females. In both types of …

An abnormal chromosome number, a condition known as aneuploidy, is a ubiquitous feature
of cancer cells. A number of studies have shown that aneuploidy impairs cellular fitness …

Essential genes tend to be highly conserved across eukaryotes, but, in some cases, their
critical roles can be bypassed through genetic rewiring. From a systematic analysis of 728 …