Highlights•Cytosolic channels in the myelin sheath are critical for axonal integrity.•Activity-
dependent vesicular release and transmitter signaling regulate myelination.•Glutamate …

Decades of research have produced no effective method to prevent, delay the onset, or slow
the progression of Alzheimer's disease (AD). In contrast to these failures …

Functional changes of white matter are largely unexplored in patients with psychiatric
disorders. This study examined white matter dysfunctions common in four major psychiatric …

Alzheimer's disease (AD) is the most common cause of age-related neurodegeneration and
dementia, and there are no available treatments with proven disease-modifying actions. It is …

Oligodendrocytes are the myelinating cells of the CNS, producing the insulating myelin
sheath that facilitates rapid electrical conduction of axonal action potentials …

Anticholinergic drugs based on tropane alkaloids, including atropine, scopolamine, and
hyoscyamine, have been used for various medicinal and toxic purposes for millennia. These …

Vitamin B5 (d-pantothenic acid; pantothenate) is an essential trace nutrient that functions as
the obligate precursor of coenzyme A (CoA), through which it plays key roles in myriad …

Schwann cells play a critical role in the development of the peripheral nervous system
(PNS), establishing important relationships both with the extracellular milieu and other cell …

This article reviews the role of neuronal activity in myelin regeneration and the related
neural signaling pathways. The article points out that neuronal activity can stimulate the …

Parkinson's disease (PD) is a progressive neurodegenerative disease characterized by
resting tremor, bradykinesia, rigidity, and postural instability that also includes non-motor …