[HTML][HTML] Neutrophils in COVID-19

N Reusch, E De Domenico, L Bonaguro… - Frontiers in …, 2021 - frontiersin.org
Strong evidence has been accumulated since the beginning of the COVID-19 pandemic that
neutrophils play an important role in the pathophysiology, particularly in those with severe …

Neutrophils as emerging therapeutic targets

T Németh, M Sperandio, A Mócsai - Nature reviews Drug discovery, 2020 - nature.com
Neutrophils are the most abundant circulating leukocytes, being the first line of defence
against bacterial and fungal infections. However, neutrophils also contribute to tissue …

[HTML][HTML] British Thoracic Society Guideline for bronchiectasis in adults

AT Hill, AL Sullivan, JD Chalmers, A De Soyza… - Thorax, 2019 - thorax.bmj.com
CT scanning can also aid in identifying an aetiology of bronchiectasis eg Allergic
bronchopulmonary aspergillosis (ABPA), Non-tuberculous mycobacteria (NTM), primary …

[HTML][HTML] Neutrophil elastase and chronic lung disease

JA Voynow, M Shinbashi - Biomolecules, 2021 - mdpi.com
Neutrophil elastase (NE) is a major inflammatory protease released by neutrophils and is
present in the airways of patients with cystic fibrosis (CF), chronic obstructive pulmonary …

[HTML][HTML] Neutrophils in the pathogenesis of rheumatoid arthritis and systemic lupus erythematosus: same foe different MO

M Fresneda Alarcon, Z McLaren, HL Wright - Frontiers in immunology, 2021 - frontiersin.org
Dysregulated neutrophil activation contributes to the pathogenesis of autoimmune diseases
including rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). Neutrophil …

[HTML][HTML] Rheumatoid arthritis synovial fluid neutrophils drive inflammation through production of chemokines, reactive oxygen species, and neutrophil extracellular …

HL Wright, M Lyon, EA Chapman, RJ Moots… - Frontiers in …, 2021 - frontiersin.org
Rheumatoid arthritis (RA) is a chronic inflammatory disorder affecting synovial joints.
Neutrophils are believed to play an important role in both the initiation and progression of …

Bronchiectasis

JD Chalmers, AB Chang, SH Chotirmall… - Nature reviews Disease …, 2018 - nature.com
Bronchiectasis refers to abnormal dilatation of the bronchi. Airway dilatation can lead to
failure of mucus clearance and increased risk of infection. Pathophysiological mechanisms …

Neutrophil elastase activity is associated with exacerbations and lung function decline in bronchiectasis

JD Chalmers, KL Moffitt, G Suarez-Cuartin… - American journal of …, 2017 - atsjournals.org
Rationale: Sputum neutrophil elastase and serum desmosine, which is a linked marker of
endogenous elastin degradation, are possible biomarkers of disease severity and …

Neutrophil extracellular traps in chronic lung disease: implications for pathogenesis and therapy

HR Keir, JD Chalmers - European Respiratory Review, 2022 - Eur Respiratory Soc
Neutrophilic inflammation has a key role in the pathophysiology of multiple chronic lung
diseases. The formation of neutrophil extracellular traps (NETs) has emerged as a key …

[HTML][HTML] Targeting neutrophils to treat acute respiratory distress syndrome in coronavirus disease

CC Chiang, M Korinek, WJ Cheng… - Frontiers in …, 2020 - frontiersin.org
This review describes targeting neutrophils as a potential therapeutic strategy for acute
respiratory distress syndrome (ARDS) associated with coronavirus disease 2019 (COVID …