Amino acids and its pharmaceutical applications: A mini review

A Bongioanni, MS Bueno, BA Mezzano… - International Journal of …, 2022 - Elsevier
Amino acids are natural compounds that can be safely used in pharmaceutical applications.
Considering the great interest in the amino acids used in the pharmaceutical industry, this …

[HTML][HTML] Cocrystals by design: a rational coformer selection approach for tackling the API problems

M Singh, H Barua, VGSS Jyothi, MR Dhondale… - Pharmaceutics, 2023 - mdpi.com
Active pharmaceutical ingredients (API) with unfavorable physicochemical properties and
stability present a significant challenge during their processing into final dosage forms …

[HTML][HTML] Amino acids as the potential co-former for co-crystal development: a review

I Nugrahani, MA Jessica - Molecules, 2021 - mdpi.com
Co-crystals are one of the most popular ways to modify the physicochemical properties of
active pharmaceutical ingredients (API) without changing pharmacological activity through …

[HTML][HTML] Mechanical Activation by Ball Milling as a Strategy to Prepare Highly Soluble Pharmaceutical Formulations in the Form of Co-Amorphous, Co-Crystals, or …

LM Martínez, J Cruz-Angeles, M Vázquez-Dávila… - Pharmaceutics, 2022 - mdpi.com
Almost half of orally administered active pharmaceutical ingredients (APIs) have low
solubility, which affects their bioavailability. In the last two decades, several alternatives …

Functional materials based on molecules with hydrogen-bonding ability: applications to drug co-crystals and polymer complexes

KM Hutchins - Royal Society open science, 2018 - royalsocietypublishing.org
The design, synthesis and property characterization of new functional materials has
garnered interest in a variety of fields. Materials that are capable of recognizing and binding …

[HTML][HTML] Application of ionic liquid to enhance the nose-to-brain delivery of etodolac

H Tanigawa, N Suzuki, T Suzuki - European Journal of Pharmaceutical …, 2022 - Elsevier
The purpose of this study was to enhance the delivery of Etodolac (ETD) to the brain through
intranasal administration using an ionic liquid (IL) consisting of ETD and proline ethyl ester …

In vitro polyploid induction using colchicine for Zingiber Officinale Roscoe cv. 'Fengtou' ginger

J Zhou, F Guo, J Fu, Y Xiao, J Wu - Plant Cell, Tissue and Organ Culture …, 2020 - Springer
Abstract 'Fengtou'ginger is a high quality ginger (Zingiber Officinale Roscoe) cultivar only
planted in Laifeng County, Enshi, Huhei, China, and is a National Product of Geographical …

[HTML][HTML] Salt cocrystal of diclofenac sodium-l-proline: Structural, pseudopolymorphism, and pharmaceutics performance study

I Nugrahani, RA Kumalasari, WN Auli, A Horikawa… - Pharmaceutics, 2020 - mdpi.com
Previously, we have reported on a zwitterionic cocrystal of diclofenac acid and L-proline.
However, the solubility of this multicomponent crystal was still lower than that of diclofenac …

[HTML][HTML] Challenges and progress in nonsteroidal anti-inflammatory drugs co-crystal development

I Nugrahani, RD Parwati - Molecules, 2021 - mdpi.com
Co-crystal innovation is an opportunity in drug development for both scientists and industry.
In line with the “green pharmacy” concept for obtaining safer methods and advanced …

In Situ Cocrystallization via Spray Drying with Polymer as a Strategy to Prevent Cocrystal Dissociation

SZ Shao, MW Stocker, S Zarrella, TM Korter… - Molecular …, 2023 - ACS Publications
The aim of the present study was to investigate how different polymers affect the dissociation
of cocrystals prepared by co-spray-drying active pharmaceutical ingredient (API), coformer …