Chlamydia trachomatis is the most common sexually transmitted bacterial pathogen and the
causative agent of blinding trachoma. Although Chlamydia is protected from humoral …

MHC class II molecules are pivotal for the adaptive immune system, because they guide the
development and activation of CD4+ T helper cells. Fulfilling these functions requires that …

We previously reported the disruption of the murine gene encoding the transcription factor
USF2 and its consequences on glucose-dependent gene regulation in the liver. We report …

Nucleotide-binding oligomerization domain (NOD)-like receptors, also known as nucleotide-
binding leucine-rich repeat receptors (NLRs), are a family of cytosolic pattern recognition …

In higher organisms a variety of host defense mechanisms control the resident microflora
and, in most cases, effectively prevent invasive microbial disease. However, it appears that …

The bare lymphocyte syndrome (BLS) is a hereditary immunodeficiency resulting from the
absence of major istocompatibility complex class II (MHCII) expression. Considering the …

Chlamydia trachomatis sexually transmitted infections cause considerable morbidity and
socioeconomic burden worldwide, despite significant advances in our understanding of the …

Microbial pathogens have been selected for the capacity to evade or manipulate host
responses in order to survive after infection. Chlamydia, an obligate intracellular pathogen …

Macrophages function at the front line of immune defences against incoming pathogens. But
the ability of macrophages to internalize bacteria, migrate, recruit other immune cells to the …

ABSTRACT CD4+ T-helper type 1 (Th1) responses are essential for the resolution of a
primary Chlamydia trachomatis genital tract infection; however, elements of the immune …