Abstract Treatment outcomes for major depressive disorder (MDD) need to be improved.
Presently, no clinically relevant tools have been established for stratifying subgroups or …

Psychiatric disorders encompass complex aberrations of cognition and affect and are
among the most debilitating and poorly understood of any medical condition. Current …

Objective: Depression is the leading cause of disability worldwide, and half of patients with
depression have treatment-resistant depression. Intermittent theta-burst stimulation (iTBS) is …

Deep brain stimulation is a promising treatment for neuropsychiatric conditions such as
major depression. It could be optimized by identifying neural biomarkers that trigger therapy …

Deep brain stimulation is a promising treatment for severe depression, but lack of efficacy in
randomized trials raises questions regarding anatomical targeting. We implanted multi-site …

Background Deep brain stimulation (DBS) of the subcallosal cingulate white matter has
shown promise as an intervention for patients with chronic, unremitting depression. To test …

Target identification and contact selection are known contributors to variability in efficacy
across different clinical indications of deep brain stimulation surgery. A retrospective …

The field of stereotactic neurosurgery developed more than 70 years ago to address a
therapy gap for patients with severe psychiatric disorders. In the decades since, it has …

Deep brain stimulation (DBS) has been successfully used to treat movement disorders, such
as Parkinson's disease, for more than 25 years and heralded the advent of electrical …

The success of deep brain stimulation (DBS) for treating Parkinson's disease has led to its
application to several other disorders, including treatment-resistant depression. Results with …