The ryanodine receptors (RyRs) are a family of Ca2+ release channels found on
intracellular Ca2+ storage/release organelles. The RyR channels are ubiquitously …

The calcium ion (Ca2+) is the simplest and most versatile intracellular messenger known.
The discovery of Ca2+ sparks and a related family of elementary Ca2+ signaling events has …

Calcium is a ubiquitous second messenger used to regulate a wide range of cellular
processes. This role in signalling has to be conducted against the rigid homeostatic …

Mathematical modeling of the cardiac action potential has proven to be a powerful tool for
illuminating various aspects of cardiac function, including cardiac arrhythmias. However, no …

Sydney Ringer would be overwhelmed today by the implications of his simple experiment
performed over 120 years ago showing that the heart would not beat in the absence of …

The control of calcium release from intracellular stores (the sarcoplasmic reticulum) in
cardiac muscle was examined with the use of a confocal microscope and voltage clamp …

Triggered activity in cardiac muscle and intracellular Ca2+ have been linked in the past.
However, today not only are there a number of cellular proteins that show clear Ca2+ …

Background—Computational biology is a powerful tool for elucidating arrhythmogenic
mechanisms at the cellular level, where complex interactions between ionic processes …

The interactions between mathematics and physiology have a long and illustrious history, of
which the study of calcium signalling is but a small chapter. Nevertheless, for those involved …

In cardiac muscle, release of activator calcium from the sarcoplasmic reticulum occurs by
calcium-induced calcium release through ryanodine receptors (RyRs), which are clustered …