Separation/extraction, detection, and interpretation of DNA mixtures in forensic science

R Tao, S Wang, J Zhang, J Zhang, Z Yang… - International journal of …, 2018 - Springer
Interpreting mixed DNA samples containing material from multiple contributors has long
been considered a major challenge in forensic casework, especially when encountering low …

The advances in DNA mixture interpretation

J Yang, D Lin, C Deng, Z Li, Y Pu, Y Yu, K Li… - Forensic science …, 2019 - Elsevier
In forensic genetics, the analysis of DNA in biological samples is a valuable tool for personal
identification. There is an increasing demand in analyzing of the mixed DNA which may …

Evaluation of the Microhaplotypes panel for DNA mixture analyses

P Chen, C Yin, Z Li, Y Pu, Y Yu, P Zhao, D Chen… - Forensic Science …, 2018 - Elsevier
The identification of a suspect in a DNA mixture typed with the standard short tandem repeat
polymorphism (STR) kits has faced challenges. Several improved methods or technologies …

Evaluation of large-scale highly polymorphic microhaplotypes in complex DNA mixtures analysis using RMNE method

Q Zhu, H Wang, Y Cao, Y Huang, Y Wei, Y Hu… - Forensic Science …, 2023 - Elsevier
DNA mixture interpretation is one of the most challenging problems in forensics. Complex
DNA mixtures are more difficult to analyze when there are more than two contributors or …

A 1204-single nucleotide polymorphism and insertion–deletion polymorphism panel for massively parallel sequencing analysis of DNA mixtures

HL Hwa, WC Chung, PL Chen, CP Lin, HY Li… - Forensic Science …, 2018 - Elsevier
Massively parallel sequencing (MPS) technology enables the simultaneous analysis of a
huge number of single nucleotide polymorphisms (SNPs) and insertion–deletion …

Using FastID to analyze complex SNP mixtures from indoor dust

KA Meiklejohn, MKR Scheible… - Journal of Forensic …, 2023 - Wiley Online Library
Forensically relevant single nucleotide polymorphisms (SNPs) can provide valuable
supplemental information to short tandem repeats (STRs) for investigative leads, and …

Analysis of complex DNA mixtures using massively parallel sequencing of SNPs with low minor allele frequencies

MS Petrovick, T Boettcher, P Fremont-Smith… - Forensic Science …, 2020 - Elsevier
DNA mixtures from 3 or more contributors have proven difficult to analyze using the current
state-of-the-art method of short-tandem repeat (STR) amplification followed by capillary …

Targeted sequencing of high-density SNPs provides an enhanced tool for forensic applications and genetic landscape exploration in Chinese Korean ethnic group

Q Lan, Y Lin, X Wang, X Yuan, C Shen, B Zhu - Human Genomics, 2023 - Springer
Background In this study, we present a NGS-based panel designed for sequencing 1993
SNP loci for forensic DNA investigation. This panel addresses unique challenges …

Estimating Individual Contributions to Complex DNA SNP Mixtures.

DO Ricke, P Fremont‐Smith, J Watkins… - Journal of forensic …, 2019 - Wiley Online Library
High‐throughput sequencing (HTS) of large panels of single nucleotide polymorphisms
(SNP s) provides an alternative or complimentary approach to short tandem repeats (STR s) …

Parallel computing with dna forensics data

A Michaleas, P Fremont-Smith… - 2022 IEEE High …, 2022 - ieeexplore.ieee.org
High-throughput sequencing (HTS) of single nu-cleotide polymorphisms (SNPs) provides
advanced DNA forensics capabilities including complex mixture analysis. This paper …