Programming of metabolism by adipokines during development
J Donato Jr - Nature Reviews Endocrinology, 2023 - nature.com
The intrauterine and early postnatal periods represent key developmental stages in which
an organism is highly susceptible to being permanently influenced by maternal factors and …
an organism is highly susceptible to being permanently influenced by maternal factors and …
The colorful versatility of adipocytes: white‐to‐brown transdifferentiation and its therapeutic potential in humans
Brown and brite adipocytes contribute to energy expenditure through nonshivering
thermogenesis. Though these cell types are thought to arise primarily from the de novo …
thermogenesis. Though these cell types are thought to arise primarily from the de novo …
Macrophage-derived chemokine CCL22 establishes local LN-mediated adaptive thermogenesis and energy expenditure
Y Yuan, R Hu, J Park, S Xiong, Z Wang, Y Qian… - Science …, 2024 - science.org
There is a regional preference around lymph nodes (LNs) for adipose beiging. Here, we
show that local LN removal within inguinal white adipose tissue (iWAT) greatly impairs cold …
show that local LN removal within inguinal white adipose tissue (iWAT) greatly impairs cold …
[HTML][HTML] Hormonal determinants of growth and weight gain in the human fetus and preterm infant
L Page, N Younge, M Freemark - Nutrients, 2023 - mdpi.com
The factors controlling linear growth and weight gain in the human fetus and newborn infant
are poorly understood. We review here the changes in linear growth, weight gain, lean body …
are poorly understood. We review here the changes in linear growth, weight gain, lean body …
Early postnatal interactions between beige adipocytes and sympathetic neurites regulate innervation of subcutaneous fat
While beige adipocytes have been found to associate with dense sympathetic neurites in
mouse inguinal subcutaneous white fat (iWAT), little is known about when and how this …
mouse inguinal subcutaneous white fat (iWAT), little is known about when and how this …
[HTML][HTML] DNA methylation modulates aging process in adipocytes
H Xie, X Liu, Q Zhou, T Huang, L Zhang, J Gao… - Aging and …, 2022 - ncbi.nlm.nih.gov
Aging has been recognized to be a highly complex biological health problem with a high risk
of chronic diseases, including type 2 diabetes, atherosclerosis, chronic bronchitis or …
of chronic diseases, including type 2 diabetes, atherosclerosis, chronic bronchitis or …
The postnatal leptin surge in mice is variable in both time and intensity and reflects nutritional status
AA Skowronski, ED Shaulson, RL Leibel… - International Journal of …, 2022 - nature.com
Background/objectives The murine postnatal leptin surge occurs within the first 4 weeks of
life and is critical for neuronal projection development within hypothalamic feeding circuits …
life and is critical for neuronal projection development within hypothalamic feeding circuits …
Global adipose tissue remodeling during the first month of postnatal life in mice
J Bruder, T Fromme - Frontiers in Endocrinology, 2022 - frontiersin.org
During the first month of postnatal life, adipose tissue depots of mice go through a drastic,
but transient, remodeling process. Between postnatal days 10 and 20, several white fat …
but transient, remodeling process. Between postnatal days 10 and 20, several white fat …
Dnmt3b Deficiency in Myf5+-Brown Fat Precursor Cells Promotes Obesity in Female Mice
Increasing energy expenditure through activation of brown fat thermogenesis is a promising
therapeutic strategy for the treatment of obesity. Epigenetic regulation has emerged as a key …
therapeutic strategy for the treatment of obesity. Epigenetic regulation has emerged as a key …
Intestinal gluconeogenesis controls the neonatal development of hypothalamic feeding circuits
J Estrada-Meza, J Videlo, C Bron, A Duchampt… - Molecular …, 2024 - Elsevier
Objective Intestinal gluconeogenesis (IGN) regulates adult energy homeostasis in part by
controlling the same hypothalamic targets as leptin. In neonates, leptin exhibits a neonatal …
controlling the same hypothalamic targets as leptin. In neonates, leptin exhibits a neonatal …