Advances in TRP channel drug discovery: from target validation to clinical studies

AP Koivisto, MG Belvisi, R Gaudet… - Nature reviews Drug …, 2022 - nature.com
Transient receptor potential (TRP) channels are multifunctional signalling molecules with
many roles in sensory perception and cellular physiology. Therefore, it is not surprising that …

Beyond neuronal heat sensing: diversity of TRPV1 heat-capsaicin receptor-channel functions

YM Shuba - Frontiers in Cellular Neuroscience, 2021 - frontiersin.org
Transient receptor potential vanilloid 1 (TRPV1) is a calcium-permeable ion channel best
known for its ability to be gated by the pungent constituent of red chili pepper, capsaicin, and …

Extraction, purification, bioactivity and pharmacological effects of capsaicin: a review

F Wang, Y Xue, L Fu, Y Wang, M He… - Critical Reviews in …, 2022 - Taylor & Francis
Abstract Capsaicin (trans-8-methyl-N-vanillyl-6-nonenamide), a well-known vanilloid, which
is the main spicy component in chili peppers, showing several biological activities and the …

Transient receptor potential (TRP) channels in the airway: role in airway disease

MS Grace, M Baxter, E Dubuis… - British journal of …, 2014 - Wiley Online Library
Over the last few decades, there has been an explosion of scientific publications reporting
the many and varied roles of transient receptor potential (TRP) ion channels in physiological …

Dorsal root ganglion neurons innervating skeletal muscle respond to physiological combinations of protons, ATP, and lactate mediated by ASIC, P2X, and TRPV1

AR Light, RW Hughen, J Zhang… - Journal of …, 2008 - journals.physiology.org
The adequate stimuli and molecular receptors for muscle metaboreceptors and nociceptors
are still under investigation. We used calcium imaging of cultured primary sensory dorsal …

Functional role of transient receptor potential channels in immune cells and epithelia

M Khalil, K Alliger, C Weidinger, C Yerinde… - Frontiers in …, 2018 - frontiersin.org
Transient receptor potential (TRP) ion channels are widely expressed in several tissues
throughout the mammalian organism. Originally, TRP channel physiology was focusing on …

[HTML][HTML] TRPV1: contribution to retinal ganglion cell apoptosis and increased intracellular Ca2+ with exposure to hydrostatic pressure

RM Sappington, T Sidorova, DJ Long… - … ophthalmology & visual …, 2009 - arvojournals.org
purpose. Elevated hydrostatic pressure induces retinal ganglion cell (RGC) apoptosis in
culture. The authors investigated whether the transient receptor potential vanilloid 1 …

Contribution of TRPV1 to microglia-derived IL-6 and NFκB translocation with elevated hydrostatic pressure

RM Sappington, DJ Calkins - Investigative ophthalmology & …, 2008 - iovs.arvojournals.org
purpose. The authors investigated the contributions of the transient receptor potential
vanilloid-1 receptor (TRPV1) and Ca 2+ to microglial IL-6 and nuclear factor kappa B (NFκB) …

Transient receptor potential vanilloid 1 activation induces inflammatory cytokine release in corneal epithelium through MAPK signaling

F Zhang, H Yang, Z Wang, S Mergler… - Journal of cellular …, 2007 - Wiley Online Library
In certain epithelial tissues, activation of transient receptor potential (TRP) vanilloid subtype
1 (TRPV1) by noxious stimuli induces pro‐inflammatory cytokine release, which helps to …

Targeting TRPV1-mediated autophagy attenuates nitrogen mustard-induced dermal toxicity

M Chen, X Dong, H Deng, F Ye, Y Zhao… - … and Targeted Therapy, 2021 - nature.com
Nitrogen mustard (NM) causes severe vesicating skin injury, which lacks effective targeted
therapies. The major limitation is that the specific mechanism of NM-induced skin injury is …