[HTML][HTML] The M1 and M2 paradigm of macrophage activation: time for reassessment
FO Martinez, S Gordon - F1000prime reports, 2014 - ncbi.nlm.nih.gov
Macrophages are endowed with a variety of receptors for lineage-determining growth
factors, T helper (Th) cell cytokines, and B cell, host, and microbial products. In tissues …
factors, T helper (Th) cell cytokines, and B cell, host, and microbial products. In tissues …
[HTML][HTML] Alternative activation of macrophages: mechanism and functions
S Gordon, FO Martinez - Immunity, 2010 - cell.com
The concept of an alternative pathway of macrophage activation has stimulated interest in its
definition, mechanism, and functional significance in homeostasis and disease. We assess …
definition, mechanism, and functional significance in homeostasis and disease. We assess …
M1 and M2 macrophages: the chicken and the egg of immunity
The purpose of this perspective is to describe a critical advance in understanding how
immune responses work. Macrophages are required for all animal life:'Inhibit'type …
immune responses work. Macrophages are required for all animal life:'Inhibit'type …
Diversity and dialogue in immunity to helminths
JE Allen, RM Maizels - Nature Reviews Immunology, 2011 - nature.com
The vertebrate immune system has evolved in concert with a broad range of infectious
agents, including ubiquitous helminth (worm) parasites. The constant pressure of helminth …
agents, including ubiquitous helminth (worm) parasites. The constant pressure of helminth …
IL-4 directly signals tissue-resident macrophages to proliferate beyond homeostatic levels controlled by CSF-1
SJ Jenkins, D Ruckerl, GD Thomas… - Journal of Experimental …, 2013 - rupress.org
Macrophages (MΦs) colonize tissues during inflammation in two distinct ways: recruitment of
monocyte precursors and proliferation of resident cells. We recently revealed a major role for …
monocyte precursors and proliferation of resident cells. We recently revealed a major role for …
Helminth secretions induce de novo T cell Foxp3 expression and regulatory function through the TGF-β pathway
Foxp3-expressing regulatory T (T reg) cells have been implicated in parasite-driven
inhibition of host immunity during chronic infection. We addressed whether parasites can …
inhibition of host immunity during chronic infection. We addressed whether parasites can …
A prospective view of animal and human Fasciolosis
K Cwiklinski, SM O'neill, S Donnelly… - Parasite …, 2016 - Wiley Online Library
Fasciolosis, a food‐borne trematodiasis, results following infection with the parasites,
Fasciola hepatica and Fasciola gigantica. These trematodes greatly affect the global …
Fasciola hepatica and Fasciola gigantica. These trematodes greatly affect the global …
Immunity to helminths: resistance, regulation, and susceptibility to gastrointestinal nematodes
RK Grencis - Annual review of immunology, 2015 - annualreviews.org
Helminth parasites are a highly successful group of pathogens that challenge the immune
system in a manner distinct from rapidly replicating infectious agents. Of this group …
system in a manner distinct from rapidly replicating infectious agents. Of this group …
Immunology of alveolar and cystic echinococcosis (AE and CE)
B Gottstein, P Soboslay, E Ortona, J Wang… - Advances in …, 2017 - Elsevier
Cystic and alveolar echinococcosis are severe chronic helminthic diseases caused by the
cystic growth or the intrahepatic tumour-like growth of the metacestode of Echinococcus …
cystic growth or the intrahepatic tumour-like growth of the metacestode of Echinococcus …
ILC2s and T cells cooperate to ensure maintenance of M2 macrophages for lung immunity against hookworms
Defining the immune mechanisms underlying protective immunity to helminth infection
remains an important challenge. Here we report that lung CD4+ T cells and Group 2 innate …
remains an important challenge. Here we report that lung CD4+ T cells and Group 2 innate …