Single-cell technologies, particularly single-cell RNA sequencing (scRNA-seq) methods,
together with associated computational tools and the growing availability of public data …

Nowadays, the diagnosis and treatment system of malignant tumors has increasingly tended
to be more precise and personalized. And the existing tumor models are still unable to fully …

The treatment of low-risk primary prostate cancer entails active surveillance only, while high-
risk disease requires multimodal treatment including surgery, radiation therapy, and …

Emerging evidence indicates that various cancers can gain resistance to targeted therapies
by acquiring lineage plasticity. Although various genomic and transcriptomic aberrations …

Inflammation is a hallmark of cancer. In patients with cancer, peripheral blood myeloid
expansion, indicated by a high neutrophil-to-lymphocyte ratio, associates with shorter …

Prostate cancer is heterogeneous and patients would benefit from methods that stratify those
who are likely to respond to systemic therapy. Here, we employ single-cell assays for …

When compared to other malignancies, the tumor microenvironment (TME) of primary and
castration-resistant prostate cancer (CRPC) is relatively devoid of immune infiltrates. While …

Club cells are a type of bronchiolar epithelial cell that serve a protective role in the lung and
regenerate damaged lung epithelium. Single‐cell RNA sequencing (scRNA‐seq) of young …

Single-cell analysis (SCA) could provide in-depth understanding of cell biology yet is of
great challenge. Many attempts have been made to develop novel techniques for SCA …

Tuft cells are chemosensory epithelial cells that increase in number following infection or
injury to robustly activate the innate immune response to alleviate or promote disease …