Retinal development and maturation are orchestrated by a series of interacting signalling
networks that drive the morphogenetic transformation of the anterior developing brain …

The development of the vertebrate eyes is a complex process starting from anterior-posterior
and dorso-ventral patterning of the anterior neural tube, resulting in the formation of the eye …

The crystalline lens plays an important role in the refractive vision of vertebrates by
facilitating variable fine focusing of light onto the retina. Loss of lens transparency, or …

Three embryonic tissue sources—the neural ectoderm, the surface ectoderm, and the
periocular mesenchyme—contribute to the formation of the mammalian eye. For this reason …

▪ Abstract This review provides a synthesis that combines data from classical
experimentation and recent advances in our understanding of early eye development …

The vertebrate retina is comprised of seven major cell types that are generated in
overlapping but well-defined intervals. To identify genes that might regulate retinal …

Microphthalmia, anophthalmia and coloboma (MAC) are distinct phenotypes that represent
a continuum of structural developmental eye defects. In severe bilateral cases …

Anophthalmia and microphthalmia describe, respectively, the absence of an eye and the
presence of a small eye within the orbit. The combined birth prevalence of these conditions …

The vertebrate eye comprises tissues from different embryonic origins: the lens and the
cornea are derived from the surface ectoderm, but the retina and the epithelial layers of the …

Cataract can be defined as any opacity of the crystalline lens. Congenital cataract is
particularly serious because it has the potential for inhibiting visual development, resulting in …