Simple Summary Gastric cancer (GC) is one of the most common cancers and the third
leading cause of cancer deaths worldwide, with a high frequency of recurrence and …

Claudin-4 (CLDN4) is a key component of tight junctions (TJs) in epithelial cells. CLDN4 is
overexpressed in many epithelial malignancies and correlates with cancer progression …

Glioblastoma (GBM) is the most common and aggressive primary malignant brain tumor.
The unregulated expression of Claudin-4 (CLDN4) plays an important role in tumor …

The barrier and fence functions of the claudin protein family are fundamental to tissue
integrity and human health. Increasing evidence has linked claudins to signal transduction …

Pancreatic ductal adenocarcinoma (PDAC) is one of the most fatal types of cancer due to the
relatively late diagnosis and the limited therapeutic options. Current treatment regimens …

Triple negative breast cancer (TNBC) is characterized by highly aggressive phenotype,
limited treatment options and a poor prognosis. In the present study, we examined the …

The tight junction (TJ) protein claudin-4 (CLDN4) is overexpressed in bladder urothelial
carcinoma (BUC) and correlates with cancer progression. However, the mechanism of …

Abstract Claudin (CLDN)-4 expression has been associated with malignancy in various
cancers. When CLDN4 expression was examined in oral squamous cell carcinoma (OSCC) …

Claudin-4 (CLDN4) is a tight junction protein to maintain the cancer microenvironment. We
recently reported the role of the CLDN4 not forming tight junction in the induction of …

New Findings What is the central question of this study? What is the influence of the
interaction between the matrix protein CLDN4 and the PI3K/Akt signalling pathway on …