The advent of COVID-19 and the persistent threat of infectious diseases such as
tuberculosis, malaria, influenza and HIV/AIDS remind us of the marked impact that infections …

Despite having been identified as the organism that causes tuberculosis in 1882,
Mycobacterium tuberculosis has managed to still evade our understanding of the protective …

Tuberculosis (TB) is a leading cause of mortality due to infectious disease, but the factors
determining disease progression are unclear. Transcriptional signatures associated with …

Immune-modulating therapies have revolutionized the treatment of chronic diseases,
particularly cancer. However, their success is restricted and there is a need to identify new …

Infection with Mycobacterium tuberculosis causes> 1.5 million deaths worldwide annually.
Innate immune cells are the first to encounter M. tuberculosis, and their response dictates …

Background Targeted preventive therapy for individuals at highest risk of incident
tuberculosis might impact the epidemic by interrupting transmission. We tested performance …

Blood transcriptomics have revealed major characteristics of the immune response in active
TB, but the signature early after infection is unknown. In a unique clinically and temporally …

Mycobacterium tuberculosis (Mtb) cultured axenically without detergent forms biofilm-like
cords, a clinical identifier of virulence. In lung-on-chip (LoC) and mouse models, cords in …

Great progress has been made over the past half-century, but TB remains a formidable
global health problem, particularly in low-and middle-income countries. Understanding the …

Tuberculosis (TB) is a heterogeneous disease manifesting in a subset of individuals infected
with aerosolized Mycobacterium tuberculosis (Mtb). Unlike human TB, murine infection …