[HTML][HTML] Host-directed immunotherapy of viral and bacterial infections: past, present and future
The advent of COVID-19 and the persistent threat of infectious diseases such as
tuberculosis, malaria, influenza and HIV/AIDS remind us of the marked impact that infections …
tuberculosis, malaria, influenza and HIV/AIDS remind us of the marked impact that infections …
Immune cell interactions in tuberculosis
JAL Flynn, J Chan - Cell, 2022 - cell.com
Despite having been identified as the organism that causes tuberculosis in 1882,
Mycobacterium tuberculosis has managed to still evade our understanding of the protective …
Mycobacterium tuberculosis has managed to still evade our understanding of the protective …
[HTML][HTML] Type I IFN exacerbates disease in tuberculosis-susceptible mice by inducing neutrophil-mediated lung inflammation and NETosis
L Moreira-Teixeira, PJ Stimpson, E Stavropoulos… - Nature …, 2020 - nature.com
Tuberculosis (TB) is a leading cause of mortality due to infectious disease, but the factors
determining disease progression are unclear. Transcriptional signatures associated with …
determining disease progression are unclear. Transcriptional signatures associated with …
The NK cell granule protein NKG7 regulates cytotoxic granule exocytosis and inflammation
Immune-modulating therapies have revolutionized the treatment of chronic diseases,
particularly cancer. However, their success is restricted and there is a need to identify new …
particularly cancer. However, their success is restricted and there is a need to identify new …
The Innate Immune Response to Mycobacterium tuberculosis Infection
MM Ravesloot-Chávez, E Van Dis… - Annual review of …, 2021 - annualreviews.org
Infection with Mycobacterium tuberculosis causes> 1.5 million deaths worldwide annually.
Innate immune cells are the first to encounter M. tuberculosis, and their response dictates …
Innate immune cells are the first to encounter M. tuberculosis, and their response dictates …
[HTML][HTML] Biomarker-guided tuberculosis preventive therapy (CORTIS): a randomised controlled trial
TJ Scriba, A Fiore-Gartland… - The Lancet Infectious …, 2021 - thelancet.com
Background Targeted preventive therapy for individuals at highest risk of incident
tuberculosis might impact the epidemic by interrupting transmission. We tested performance …
tuberculosis might impact the epidemic by interrupting transmission. We tested performance …
[HTML][HTML] Blood transcriptomics reveal the evolution and resolution of the immune response in tuberculosis
O Tabone, R Verma, A Singhania… - The Journal of …, 2021 - ncbi.nlm.nih.gov
Blood transcriptomics have revealed major characteristics of the immune response in active
TB, but the signature early after infection is unknown. In a unique clinically and temporally …
TB, but the signature early after infection is unknown. In a unique clinically and temporally …
[HTML][HTML] Mechanopathology of biofilm-like Mycobacterium tuberculosis cords
R Mishra, M Hannebelle, VP Patil, A Dubois… - Cell, 2023 - cell.com
Mycobacterium tuberculosis (Mtb) cultured axenically without detergent forms biofilm-like
cords, a clinical identifier of virulence. In lung-on-chip (LoC) and mouse models, cords in …
cords, a clinical identifier of virulence. In lung-on-chip (LoC) and mouse models, cords in …
[HTML][HTML] A half-century of research on tuberculosis: Successes and challenges
BR Bloom - The Journal of Experimental Medicine, 2023 - ncbi.nlm.nih.gov
Great progress has been made over the past half-century, but TB remains a formidable
global health problem, particularly in low-and middle-income countries. Understanding the …
global health problem, particularly in low-and middle-income countries. Understanding the …
[HTML][HTML] Ultra-low dose aerosol infection of mice with Mycobacterium tuberculosis more closely models human tuberculosis
Tuberculosis (TB) is a heterogeneous disease manifesting in a subset of individuals infected
with aerosolized Mycobacterium tuberculosis (Mtb). Unlike human TB, murine infection …
with aerosolized Mycobacterium tuberculosis (Mtb). Unlike human TB, murine infection …