Aging and diabetes mellitus are 2 well-known risk factors for cardiovascular disease (CVD).
During the past 50 years, there has been an dramatic increase in life expectancy with a …

Dysregulation of the endogenous lipid mediators endocannabinoids and their G-protein-
coupled cannabinoid receptors 1 and 2 (CB1R and CB2R) has been implicated in a variety …

The goal of this review is to summarize studies in which concentrations of circulating
endocannabinoids in humans have been examined in relationship to physiological …

Excess intra-abdominal adipose tissue accumulation, often termed visceral obesity, is part of
a phenotype including dysfunctional subcutaneous adipose tissue expansion and ectopic …

Epidemiological, clinical, and mechanistic preclinical studies conducted in the field of
cardiovascular medicine have led to remarkable progress in our understanding of …

Endocannabinoids and cannabinoid CB1 receptors are known to play a generalized role in
energy homeostasis. However, clinical trials with the first generation of CB1 blockers, now …

Obesity and mood disorders are highly prevalent and co-morbid. Epidemiological studies
have highlighted the public health relevance of this association, insofar as both conditions …

Obesity is characterised by altered gut microbiota, low‐grade inflammation and increased
endocannabinoid (eCB) system tone; however, a clear connection between gut microbiota …

The classical perception of adipose tissue as a storage place of fatty acids has been
replaced over the last years by the notion that adipose tissue has a central role in lipid and …

During the last decades, research on adipose tissues has spread in parallel with the
extension of obesity. Several observations converged on the idea that adipose tissues are …