The i-motif as a molecular target: more than a complementary DNA secondary structure
SL Brown, S Kendrick - Pharmaceuticals, 2021 - mdpi.com
Stretches of cytosine-rich DNA are capable of adopting a dynamic secondary structure, the i-
motif. When within promoter regions, the i-motif has the potential to act as a molecular switch …
motif. When within promoter regions, the i-motif has the potential to act as a molecular switch …
Homozygous BCMA gene deletion in response to anti-BCMA CAR T cells in a patient with multiple myeloma
MC Da Vià, O Dietrich, M Truger, P Arampatzi, J Duell… - Nature medicine, 2021 - nature.com
B cell maturation antigen (BCMA) is a target for various immunotherapies and a biomarker
for tumor load in multiple myeloma (MM). We report a case of irreversible BCMA loss in a …
for tumor load in multiple myeloma (MM). We report a case of irreversible BCMA loss in a …
[HTML][HTML] Distinct classes of complex structural variation uncovered across thousands of cancer genome graphs
Cancer genomes often harbor hundreds of somatic DNA rearrangement junctions, many of
which cannot be easily classified into simple (eg, deletion) or complex (eg, chromothripsis) …
which cannot be easily classified into simple (eg, deletion) or complex (eg, chromothripsis) …
RHO GTPases in cancer: known facts, open questions, and therapeutic challenges
XR Bustelo - Biochemical Society Transactions, 2018 - portlandpress.com
RHO GTPases have been traditionally associated with protumorigenic functions. While this
paradigm is still valid in many cases, recent data have unexpectedly revealed that RHO …
paradigm is still valid in many cases, recent data have unexpectedly revealed that RHO …
Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes
Intra-tumor heterogeneity (ITH) is a mechanism of therapeutic resistance and therefore an
important clinical challenge. However, the extent, origin, and drivers of ITH across cancer …
important clinical challenge. However, the extent, origin, and drivers of ITH across cancer …
The genomic landscape of 85 advanced neuroendocrine neoplasms reveals subtype-heterogeneity and potential therapeutic targets
Metastatic and locally-advanced neuroendocrine neoplasms (aNEN) form clinically and
genetically heterogeneous malignancies, characterized by distinct prognoses based upon …
genetically heterogeneous malignancies, characterized by distinct prognoses based upon …
CancerMine: a literature-mined resource for drivers, oncogenes and tumor suppressors in cancer
Tumors from individuals with cancer are frequently genetically profiled for information about
the driving forces behind the disease. We present the CancerMine resource, a text-mined …
the driving forces behind the disease. We present the CancerMine resource, a text-mined …
Enzyme-mediated depletion of methylthioadenosine restores T cell function in MTAP-deficient tumors and reverses immunotherapy resistance
Chromosomal region 9p21 containing tumor suppressors CDKN2A/B and
methylthioadenosine phosphorylase (MTAP) is one of the most frequent genetic deletions in …
methylthioadenosine phosphorylase (MTAP) is one of the most frequent genetic deletions in …
Circular RNA circ‐TNPO3 inhibits clear cell renal cell carcinoma metastasis by binding to IGF2BP2 and destabilizing SERPINH1 mRNA
X Pan, B Huang, Q Ma, J Ren, Y Liu… - Clinical and …, 2022 - Wiley Online Library
Background Clear cell renal cell carcinoma (ccRCC) is a common malignant tumour of the
urinary tract. The major causes of poor prognosis are the lack of early diagnosis and …
urinary tract. The major causes of poor prognosis are the lack of early diagnosis and …
MEDICC2: whole-genome doubling aware copy-number phylogenies for cancer evolution
Aneuploidy, chromosomal instability, somatic copy-number alterations, and whole-genome
doubling (WGD) play key roles in cancer evolution and provide information for the complex …
doubling (WGD) play key roles in cancer evolution and provide information for the complex …