Plaque development and rupture are hallmarks of atherosclerotic vascular disease. Despite
current therapeutic developments, there is an unmet necessity in the prevention of …

In the 1900s, researchers established animal models experimentally to induce
atherosclerosis by feeding them with a cholesterol-rich diet. It is now accepted that high …

Background: Coronary lesions with low fractional flow reserve (FFR) that are treated
medically are associated with higher revascularization rates. High wall shear stress (WSS) …

Aims Acute coronary syndromes with intact fibrous cap (IFC-ACS), ie caused by coronary
plaque erosion, account for approximately one-third of ACS. However, the underlying …

The leading cause of heart disease in developed countries is coronary atherosclerosis,
which is not simply a result of ageing but a chronic inflammatory process that can lead to …

Aims The focal distribution of atherosclerotic plaques suggests that local biomechanical
factors may influence plaque development. Methods and results We studied 40 patients at …

Globally, cardiovascular diseases are seen as one of the largest economic burdens on
society and the single largest cause of death, with atherosclerosis the leading cause of …

Atherosclerotic cardiovascular disease is the leading cause of morbidity and mortality
worldwide. Several cardiovascular risk factors are implicated in atherosclerotic plaque …

The increasing prevalence of finite element (FE) simulations in the study of atherosclerosis
has spawned numerous inverse FE methods for the mechanical characterization of …

Background The lipid-to-cap ratio (LCR) and thin-cap fibroatheroma (TCFA) derived from
optical coherence tomography (OCT) are indicative of plaque vulnerability. Aims We aimed …