Teeth develop as ectodermal appendages from epithelial and mesenchymal tissues. Tooth
organogenesis is regulated by an intricate network of cell–cell signaling during all steps of …

Introduction: Human dental stem cells can be obtained from postnatal teeth, extracted
wisdom teeth or exfoliated deciduous teeth. Due to their differentiation potential, these …

Epithelial-mesenchymal interactions guide tooth development through its early stages and
establish the morphology of the dentin surface upon which enamel will be deposited …

The continuously growing mouse incisor serves as a valuable model to study stem cell
regulation during organ renewal. Epithelial stem cells are localized in the proximal end of …

Organogenesis depends upon a well-ordered series of inductive events involving
coordination of molecular pathways that regulate the generation and patterning of specific …

Classical tissue recombination studies demonstrated that initiation of tooth development
depends on activation of odontogenic potential in the mesenchyme by signals from the …

Mice carrying mutations in Wise (Sostdc1) display defects in many aspects of tooth
development, including tooth number, size and cusp pattern. To understand the basis of …

Despite advances in the knowledge of tooth morphogenesis and differentiation, relatively
little is known about the aetiology and molecular mechanisms underlying supernumerary …

Odonto-onycho-dermal dysplasia (OODD), a rare autosomal-recessive inherited form of
ectodermal dysplasia including severe oligodontia, nail dystrophy, palmoplantar …

Teeth are mineralized organs composed of three unique hard tissues, enamel, dentin, and
cementum, and supported by the surrounding alveolar bone. Although odontogenesis differs …