Fundamentals and developments in fluorescence-guided cancer surgery
JSD Mieog, FB Achterberg, A Zlitni… - Nature reviews Clinical …, 2022 - nature.com
Fluorescence-guided surgery using tumour-targeted imaging agents has emerged over the
past decade as a promising and effective method of intraoperative cancer detection. An …
past decade as a promising and effective method of intraoperative cancer detection. An …
Cell-penetrating peptides in diagnosis and treatment of human diseases: from preclinical research to clinical application
J Xie, Y Bi, H Zhang, S Dong, L Teng, RJ Lee… - Frontiers in …, 2020 - frontiersin.org
Cell-penetrating peptides (CPPs) are short peptides (fewer than 30 amino acids) that have
been predominantly used in basic and preclinical research during the last 30 years. Since …
been predominantly used in basic and preclinical research during the last 30 years. Since …
The current state of peptide drug discovery: back to the future?
A Henninot, JC Collins, JM Nuss - Journal of medicinal chemistry, 2018 - ACS Publications
Over the past decade, peptide drug discovery has experienced a revival of interest and
scientific momentum, as the pharmaceutical industry has come to appreciate the role that …
scientific momentum, as the pharmaceutical industry has come to appreciate the role that …
Reactive oxygen species generating systems meeting challenges of photodynamic cancer therapy
The reactive oxygen species (ROS)-mediated mechanism is the major cause underlying the
efficacy of photodynamic therapy (PDT). The PDT procedure is based on the cascade of …
efficacy of photodynamic therapy (PDT). The PDT procedure is based on the cascade of …
[HTML][HTML] Alliance with EPR effect: combined strategies to improve the EPR effect in the tumor microenvironment
The use of nanomedicine for cancer treatment takes advantage of its preferential
accumulation in tumors owing to the enhanced permeability and retention (EPR) effect. The …
accumulation in tumors owing to the enhanced permeability and retention (EPR) effect. The …
RGD-binding integrins revisited: how recently discovered functions and novel synthetic ligands (re-) shape an ever-evolving field
Simple Summary Integrins, a superfamily of cell adhesion receptors, were extensively
investigated as therapeutic targets over the last decades, motivated by their multiple …
investigated as therapeutic targets over the last decades, motivated by their multiple …
Exploring the role of RGD-recognizing integrins in cancer
M Nieberler, U Reuning, F Reichart, J Notni, HJ Wester… - Cancers, 2017 - mdpi.com
Integrins are key regulators of communication between cells and with their
microenvironment. Eight members of the integrin superfamily recognize the tripeptide motif …
microenvironment. Eight members of the integrin superfamily recognize the tripeptide motif …
Multifunctional Theranostic Nanoparticles Based on Exceedingly Small Magnetic Iron Oxide Nanoparticles for T1-Weighted Magnetic Resonance Imaging and …
The recently emerged exceedingly small magnetic iron oxide nanoparticles (ES-MIONs)(< 5
nm) are promising T 1-weighted contrast agents for magnetic resonance imaging (MRI) due …
nm) are promising T 1-weighted contrast agents for magnetic resonance imaging (MRI) due …
Are integrins still practicable targets for anti-cancer therapy?
B Alday-Parejo, R Stupp, C Rüegg - Cancers, 2019 - mdpi.com
Correlative clinical evidence and experimental observations indicate that integrin adhesion
receptors, in particular those of the αV family, are relevant to cancer cell features, including …
receptors, in particular those of the αV family, are relevant to cancer cell features, including …
Specific activation of photosensitizer with extrinsic enzyme for precisive photodynamic therapy
Delivery of functional proteins into the intracellular space has been a challenging task that
could lead to a myriad of therapeutic applications. We report herein a novel bioconjugation …
could lead to a myriad of therapeutic applications. We report herein a novel bioconjugation …