Plasmodium falciparum and Plasmodium vivax account for more than 95% of all human
malaria infections, and thus pose a serious public health challenge. To control and …

The relative contribution of founder effects and natural selection to the observed distribution
of human blood groups has been debated since blood group frequencies were shown to …

Plasmodium falciparum is the most prevalent and lethal of the malaria parasites infecting
humans, yet the origin and evolutionary history of this important pathogen remain …

Haemosporida is a large group of vector‐borne intracellular parasites that infect
amphibians, reptiles, birds, and mammals. This group includes the different malaria …

Humans have evolved much longer lifespans than the great apes, which rarely exceed 50
years. Since 1800, lifespans have doubled again, largely due to improvements in …

The high prevalence of sickle haemoglobin in Africa shows that malaria has been a major
force for human evolutionary selection, but surprisingly few other polymorphisms have been …

De novo drug design aims to generate novel chemical compounds with desirable chemical
and pharmacological properties from scratch using computer-based methods. Recently …

AB 5 toxins are important virulence factors for several major bacterial pathogens, including
Bordetella pertussis, Vibrio cholerae, Shigella dysenteriae and at least two distinct …

Darwinian evolution of humans from our common ancestors with nonhuman primates
involved many gene–environment interactions at the population level, and the resulting …

African apes harbour at least six Plasmodium species of the subgenus Laverania, one of
which gave rise to human Plasmodium falciparum. Here we use a selective amplification …