Ras oncoproteins play pivotal roles in both the development and maintenance of many
tumor types. Unfortunately, these proteins are difficult to directly target using traditional …

Metastasis is known as the most life-threatening event in cancer patients. In principle, the
immune system can prevent tumor development. However, dysfunctional T cells may fail to …

Abstract Ras-associated protein-1 (Rap1), a small GTPase in the Ras-related protein family,
is an important regulator of basic cellular functions (eg, formation and control of cell …

Worldwide,∼ 196 million are afflicted with endometriosis, a painful disease in which
endometrial tissue implants and proliferates on abdominal peritoneal surfaces. Theories on …

Abstract Background Although Mex3 RNA‐binding family member A (Mex3a) has
demonstrated an important role in multiple cancers, its role and regulatory mechanism in …

Seminal discoveries have established that epigenetic modifications are important for driving
tumor progression. Polycomb group (PcG) proteins are highly conserved epigenetic …

Abstract The metastatic Skin Cutaneous Melanoma (SKCM) has been associated with
diminished survival rates and high mortality rates worldwide. Thus, segregating metastatic …

SHARPIN, as a tumor-associated gene, is involved in the metastatic process of many kinds
of tumors. Herein, we studied the function of Shank-associated RH domain interacting …

Epigenetic aberrations have been associated with cutaneous melanoma tumorigenesis and
progression including dysregulated DNA gene promoter region methylation, histone …

Thyroid cancer is the most common type of endocrine malignancy, encompassing tumors
with various levels of invasive growth and aggressiveness. Rap1GAP, a Rap1 GTPase …