Congenital heart disease (CHD) is the most common birth defect among newborns
worldwide and contributes to significant infant morbidity and mortality. Owing to major …

Congenital heart diseases (CHDs) are structural or functional defects present at birth due to
improper heart development. Current therapeutic approaches to treating severe CHDs are …

Abstract The 22q11. 2 deletion syndrome (22q11DS; velocardiofacial/DiGeorge syndrome;
VCFS/DGS; MIM# 192430; 188400) is the most common microdeletion syndrome. The …

The differentiation of ESCs into cardiomyocytes in vitro is an excellent and reliable model
system for studying normal cardiomyocyte development in mammals, modeling cardiac …

Many factors and molecular pathways are involved in the pathogenesis of arterial
hypertension. The increase in blood pressure may be determined by the properties of …

Embryonic signaling pathways exert stage-specific effects during cardiac development, yet
the precise signals for proliferation or maturation remain elusive. To uncover the cues for …

The goal of this study was to explore the role of tumor associated long noncoding RNA
expressed on chromosome 2 (TALNEC2) in protecting against myocardial ischemic injury …

This study aimed to investigate the role and regulatory mechanism of small nucleolar RNA
host gene 6 (SNHG6), a long noncoding RNA, in the formation of ventricular septal defect …

MicroRNA 145 (miR-145) is a critical modulator of cardiovascular diseases. The
downregulation of myocardial miR-145 is followed by an increase in disabled-2 (Dab2) …

Contractility of the adult heart relates to the architectural degree of sarcomeres in individual
cardiomyocytes (CMs) and appears to be inversely correlated with the ability to regenerate …